STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ribKCTP-dependent riboflavin kinase; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (121 aa)    
Predicted Functional Partners:
ribL
FMN adenylyltransferase; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
     
 0.928
Mfer_0200
COGs: COG1731 riboflavin synthase; InterPro IPR002180: IPR006399; KEGG: mth:MTH134 riboflavin synthase; PFAM: 67-dimethyl-8-ribityllumazine synthase; PRIAM: Riboflavin synthase; SPTR: Q59587 Riboflavin synthase; TIGRFAM: riboflavin synthase; PFAM: 6,7-dimethyl-8-ribityllumazine synthase; TIGRFAM: riboflavin synthase.
    
  0.913
sepS
phosphoserine-tRNA(Cys) ligase; Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
     
 0.838
Mfer_0344
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
       0.808
rad50
SMC domain protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily.
       0.768
Mfer_0340
Mur ligase middle domain protein; COGs: COG0771 UDP-N-acetylmuramoylalanine-D-glutamate ligase; InterPro IPR013221: IPR006115: IPR016040; KEGG: mth:MTH532 UDP-N-acetylmuramyl tripeptide synthetase related protein; PFAM: Mur ligase middle domain protein; 6-phosphogluconate dehydrogenase NAD-binding; SPTR: O26632 UDP-N-acetylmuramyl tripeptide synthetase related protein; PFAM: Mur ligase middle domain.
       0.768
Mfer_0341
Radical SAM domain protein; COGs: COG1180 Pyruvate-formate lyase-activating enzyme; InterPro IPR016431: IPR007197; KEGG: mtp:Mthe_1490 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; SPTR: C8S6S9 Radical SAM domain protein; PFAM: Radical SAM superfamily.
       0.768
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.
 
     0.676
Mfer_0440
Protein of unknown function DUF359; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
  
     0.623
tiaS
tRNA(Ile2) 2-agmatinylcytidine synthetase; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
  
     0.620
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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