STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0367Dihydropteroate synthase-related protein; COGs: COG0294 Dihydropteroate synthase; InterPro IPR000489: IPR005236: IPR011005; KEGG: mth:MTH1741 hypothetical protein; PFAM: dihydropteroate synthase DHPS; SPTR: O27773 Conserved protein; TIGRFAM: dihydropteroate synthase-related protein; PFAM: Pterin binding enzyme; TIGRFAM: dihydropteroate synthase-related protein. (521 aa)    
Predicted Functional Partners:
Mfer_0582
COGs: COG2054 Uncharacterized kinase related to aspartokinase uridylate kinase; InterPro IPR011375: IPR001048; KEGG: mth:MTH1698 delta 1-pyrroline-5-carboxylate synthetase; PFAM: aspartate/glutamate/uridylate kinase; SPTR: O27733 Delta 1-pyrroline-5-carboxylate synthetase; PFAM: Amino acid kinase family.
 
   
 0.832
mfnB
Protein of unknown function DUF556; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).
 
   
 0.830
Mfer_0368
PP-loop domain protein; COGs: COG0037 ATPase of the PP-loop superfamily protein implicated in cell cycle control; InterPro IPR012089: IPR000541: IPR011063: IPR014729; KEGG: msi:Msm_0553 PP family ATPase; PFAM: PP-loop domain protein; SPTR: A5UKN0 ATPase, PP-loop superfamily; PFAM: PP-loop family; TIGRFAM: conserved hypothetical protein TIGR00269.
     
 0.802
Mfer_0206
Beta-ribofuranosylaminobenzene 5'-phosphate synthase family; Catalyzes the condensation of 4-aminobenzoate (pABA) with 5- phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta- ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
 
     0.792
Mfer_1266
Protein of unknown function DUF447; COGs: COG2457 conserved hypothetical protein; InterPro IPR016733: IPR007386; KEGG: mth:MTH863 hypothetical protein; PFAM: protein of unknown function DUF447; SPTR: O26951 Uncharacterized protein MTH_863; PFAM: Protein of unknown function (DUF447).
 
   
 0.760
Mfer_0908
dITPase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
  
 0.757
Mfer_0209
H4MPT-linked C1 transfer pathway protein; COGs: COG1548 transcriptional regulator/sugar kinase; InterPro IPR002821: IPR002756; KEGG: mth:MTH834 hypothetical protein; PFAM: Hydantoinase/oxoprolinase; SPTR: O26922 Conserved protein; TIGRFAM: H4MPT-linked C1 transfer pathway protein; PFAM: Hydantoinase/oxoprolinase; TIGRFAM: probable H4MPT-linked C1 transfer pathway protein.
 
   
 0.754
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
  
  
 0.751
Mfer_1096
COGs: COG2037 Formylmethanofuran:tetrahydromethanopterin formyltransferase; InterPro IPR014053: IPR002770; KEGG: mth:MTH403 formylmethanofuran--tetrahydromethanopterin formyltransferase; PFAM: formylmethanofuran: tetrahydromethanopterin formyltransferase (Ftr); PRIAM: Formylmethanofuran--tetrahydromethanopterin N-formyltransferase; SPTR: O26503 Formylmethanofuran--tetrahydromethanopterin formyltransferase-like protein; PFAM: FTR, proximal lobe; lobe; TIGRFAM: formylmethanofuran--tetrahydromethanopterin N-formyltransferase.
 
   
 0.746
Mfer_0210
Protein of unknown function DUF201; COGs: COG1821 ATP-utilizing protein (ATP-grasp superfamily); InterPro IPR011761: IPR003806; KEGG: mth:MTH835 hypothetical protein; PFAM: protein of unknown function DUF201; SPTR: O26923 Conserved protein; PFAM: ATP-grasp domain.
  
   
 0.741
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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