STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (423 aa)    
Predicted Functional Partners:
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
 0.999
aroE
Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
 0.986
aroK
COGs: COG1685 shikimate kinase; InterPro IPR006203: IPR010189: IPR014721: IPR020568: IPR 006204: IPR013750; KEGG: mth:MTH805 shikimate kinase; PFAM: GHMP kinase; GHMP kinase domain protein; SPTR: O26896 Shikimate kinase; TIGRFAM: shikimate kinase; PFAM: GHMP kinases C terminal; GHMP kinases N terminal domain; TIGRFAM: shikimate kinase.
    
  0.933
Mfer_0679
Chorismate mutase, type II; InterPro IPR020822: IPR002701; KEGG: mth:MTH804 chorismate mutase; PFAM: Chorismate mutase, type II; SPTR: O26895 Chorismate mutase, subunit A; PFAM: Chorismate mutase type II; TIGRFAM: chorismate mutase, archaeal type.
  
  
 0.924
Mfer_0030
COGs: COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; InterPro IPR020845: IPR000169: IPR000873; KEGG: mth:MTH657 AMP-binding domain protein; PFAM: AMP-dependent synthetase and ligase; SPTR: O26753 Long-chain-fatty-acid-CoA ligase; PFAM: AMP-binding enzyme.
    
 0.904
Mfer_0415
COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR020845: IPR000873; KEGG: mba:Mbar_A2172 AMP-binding protein; PFAM: AMP-dependent synthetase and ligase; SPTR: Q0PVA7 Acetyl-CoA synthetase related protein; PFAM: AMP-binding enzyme.
    
 0.842
valS
valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
  
    0.819
aroD
3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family.
 
  
 0.796
hisC
COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR015424: IPR004839: IPR015421: IPR015422: IPR 005861; KEGG: mth:MTH1587 histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; SPTR: O27624 Histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase.
 
  
 0.782
Mfer_0242
COGs: COG0077 Prephenate dehydratase; InterPro IPR001086: IPR018528: IPR002912; KEGG: mth:MTH1220 chorismate mutase; PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; PRIAM: Prephenate dehydratase; SPTR: O27288 Chorismate mutase; PFAM: Prephenate dehydratase; ACT domain.
 
  
 0.774
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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