STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0373Protein of unknown function UPF0047; COGs: COG0432 conserved hypothetical protein; InterPro IPR001602; KEGG: mth:MTH771 hypothetical protein; PFAM: protein of unknown function UPF0047; SPTR: O26865 UPF0047 protein MTH_771; PFAM: Uncharacterised protein family UPF0047; TIGRFAM: secondary thiamine-phosphate synthase enzyme. (136 aa)    
Predicted Functional Partners:
Mfer_0899
COGs: COG0142 Geranylgeranyl pyrophosphate synthase; InterPro IPR000092: IPR008949; KEGG: mth:MTH50 bifunctional short chain isoprenyl diphosphate synthase; PFAM: Polyprenyl synthetase; PRIAM: Dimethylallyltranstransferase; SPTR: Q53479 Bifunctional short chain isoprenyl diphosphate synthase; PFAM: Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family.
    
 0.778
ribL
FMN adenylyltransferase; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
      0.716
Mfer_0374
Hypothetical protein; KEGG: mth:MTH995 lysyl endopeptidase; SPTR: O27076 Lysyl endopeptidase.
       0.558
Mfer_0845
COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006140: IPR006236: IPR016040: IPR006139: IPR 002912; KEGG: mth:MTH970 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein; PRIAM: Phosphoglycerate dehydrogenase; SPTR: O27051 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specifi [...]
     
 0.547
tpiA
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
 
   
 0.454
Mfer_0375
Small nuclear ribonucleoprotein, LSM family; COGs: COG1958 Small nuclear ribonucleoprotein (snRNP) homolog; InterPro IPR006649: IPR010920: IPR001163; KEGG: mth:MTH649 small nuclear ribonucleoprotein; PFAM: Like-Sm ribonucleoprotein core; SMART: Sm-family ribonucleoprotein; SPTR: O26745 Putative snRNP Sm-like protein; PFAM: LSM domain; Belongs to the snRNP Sm proteins family.
  
    0.447
tgtA
Archaeosine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family.
       0.428
rpl37e
LSU ribosomal protein L37E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family.
  
    0.421
Mfer_0424
Peptidase A24A domain protein; InterPro IPR000045: IPR009639; KEGG: mth:MTH421 hypothetical protein; PFAM: Peptidase A24A domain protein; peptidase A24A prepilin type IV; SPTR: O26521 Uncharacterized protein MTH_421; PFAM: Type IV leader peptidase family; Archaeal Peptidase A24 C-terminal Domain.
  
    0.408
thiL
Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
 
   
 0.408
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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