STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0426Flavodoxin/nitric oxide synthase; COGs: COG0426 flavoprotein; InterPro IPR008254: IPR016440; KEGG: mvu:Metvu_0447 beta-lactamase domain protein; PFAM: flavodoxin/nitric oxide synthase; SPTR: C9RFF4 Beta-lactamase domain protein; PFAM: Metallo-beta-lactamase superfamily; Flavodoxin. (406 aa)    
Predicted Functional Partners:
Mfer_0405
FAD-dependent pyridine nucleotide-disulfide oxidoreductase; COGs: COG1251 NAD(P)H-nitrite reductase; InterPro IPR013027: IPR016156: IPR004099; KEGG: mth:MTH1354 NADH oxidase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: O27407 NADH oxidase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain.
   
 0.954
Mfer_0425
Rubrerythrin; COGs: COG1592 Rubrerythrin; InterPro IPR009040: IPR009078: IPR003251: IPR012347; KEGG: mfe:Mefer_1068 rubrerythrin; PFAM: Rubrerythrin; SPTR: C7P8J7 Rubrerythrin; PFAM: Rubrerythrin.
  
  
 0.884
Mfer_0039
Desulfoferrodoxin ferrous iron-binding region; COGs: COG2033 Desulfoferrodoxin; InterPro IPR002742; KEGG: mvu:Metvu_0440 superoxide reductase; PFAM: Desulfoferrodoxin ferrous iron-binding region; SPTR: C5U740 Desulfoferrodoxin ferrous iron-binding region; PFAM: Desulfoferrodoxin; TIGRFAM: desulfoferrodoxin ferrous iron-binding domain.
 
  
 0.791
Mfer_0902
COGs: COG2033 Desulfoferrodoxin; InterPro IPR004462: IPR004793: IPR002742; KEGG: mth:MTH757 rubredoxin oxidoreductase; PFAM: Desulfoferrodoxin ferrous iron-binding region; Desulfoferrodoxin Dfx domain protein; SPTR: O26851 Desulfoferrodoxin homolog; TIGRFAM: desulfoferrodoxin; PFAM: Desulfoferrodoxin; Desulfoferrodoxin, N-terminal domain; TIGRFAM: desulfoferrodoxin FeS4 iron-binding domain; desulfoferrodoxin; desulfoferrodoxin ferrous iron-binding domain.
 
  
 0.747
cofD
LPPG:FO 2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.
     
 0.597
cofC
Phospholactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family.
      
 0.588
Mfer_0038
1-Cys peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
  
  
 0.561
tfb
Transcription initiation factor IIB (TFIIB); Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
      
 0.561
psmA
Proteasome endopeptidase complex, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
      
 0.561
Mfer_1105
COGs: COG1035 Coenzyme F420-reducing hydrogenase beta subunit; InterPro IPR017896: IPR007525: IPR001450: IPR007516: IPR 017900; KEGG: mth:MTH193 coenzyme F420-reducing hydrogenase, beta subunit-like protein; PFAM: coenzyme F420 hydrogenase/dehydrogenase beta subunit domain protein; 4Fe-4S ferredoxin iron-sulfur binding domain protein; PRIAM: Coenzyme F420 hydrogenase; SPTR: O26295 Coenzyme F420-reducing hydrogenase, beta subunit homolog; PFAM: Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus.
      
 0.546
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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