STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
rfcLAAA ATPase; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (405 aa)    
Predicted Functional Partners:
Mfer_0045
MCM family protein; COGs: COG1241 ATPase involved in replication control Cdc46/Mcm family; InterPro IPR016027: IPR001208: IPR006141: IPR004042: IPR 018525: IPR012340: IPR003587: IPR003586: IPR006142; KEGG: mem:Memar_1247 MCM family protein; PFAM: MCM family protein; SMART: MCM family protein; Hedgehog/intein hint domain protein; SPTR: A3CUX8 Replicative DNA helicase Mcm / Intein; PFAM: MCM2/3/5 family; TIGRFAM: intein N-terminal splicing region; intein C-terminal splicing region; Belongs to the MCM family.
 
 
 0.991
pcn
Monomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
 
 0.979
rfcS
Replication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily.
 
   
0.919
Mfer_0181
Nucleic acid binding OB-fold tRNA/helicase-type; COGs: COG1599 Single-stranded DNA-binding replication protein A (RPA) large (70 kD) subunit and related ssDNA-binding protein; InterPro IPR016027: IPR004365: IPR012340; KEGG: mth:MTH1385 replication factor A; PFAM: nucleic acid binding OB-fold tRNA/helicase-type; SPTR: O27438 Replication factor A related protein; PFAM: Replication factor-A C terminal domain; OB-fold nucleic acid binding domain.
  
 0.903
priL
DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
  
 0.896
fen
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]
  
 0.889
priS
DNA primase, small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...]
   
 0.887
lig
DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
  
 0.881
Mfer_0221
COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR006134; KEGG: mth:MTH208 DNA-dependent DNA polymerase family B protein; PFAM: DNA polymerase B region; SPTR: O26310 DNA-dependent DNA polymerase family B (PolB2); PFAM: DNA polymerase family B.
   
 0.861
Mfer_0904
COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR017964: IPR017966: IPR012337: IPR006133: IPR 006134: IPR006172; KEGG: mth:MTH1208 DNA-dependent DNA polymerase family B protein; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; PRIAM: DNA-directed DNA polymerase; SMART: DNA-directed DNA polymerase B; SPTR: O27276 DNA polymerase; PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain.
   
 0.861
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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