STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0456COGs: COG1047 FKBP-type peptidyl-prolyl cis-trans isomerase 2; InterPro IPR001179; KEGG: mth:MTH1125 fkbp-type peptidyl-prolyl cis-trans isomerase; PFAM: peptidylprolyl isomerase FKBP-type; SPTR: O27197 Fkbp-type peptidyl-prolyl cis-trans isomerase; PFAM: FKBP-type peptidyl-prolyl cis-trans isomerase. (238 aa)    
Predicted Functional Partners:
rps2
COGs: COG0052 Ribosomal protein S2; InterPro IPR018130: IPR005707: IPR001865; KEGG: mth:MTH44 30S ribosomal protein S2; PFAM: ribosomal protein S2; SPTR: O26150 30S ribosomal protein S2P; TIGRFAM: ribosomal protein S2; PFAM: Ribosomal protein S2; TIGRFAM: ribosomal protein Sa(cytosolic)/S2(archaeal); Belongs to the universal ribosomal protein uS2 family.
  
 
 0.924
rps3
SSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family.
  
 
 0.872
Mfer_0455
Protein of unknown function DUF795; COGs: COG1323 nucleotidyltransferase; InterPro IPR008513; KEGG: mth:MTH1126 hypothetical protein; PFAM: protein of unknown function DUF795; SPTR: O27198 UPF0348 protein MTH_1126; PFAM: Protein of unknown function (DUF795).
       0.870
Mfer_0402
Hydrogenase accessory protein HypB; COGs: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; InterPro IPR012202: IPR004392: IPR003495; KEGG: mth:MTH782 hydrogenase expression/formation protein HypB; PFAM: cobalamin synthesis protein P47K; SPTR: O26875 Hydrogenase expression/formation protein HypB; TIGRFAM: hydrogenase accessory protein HypB; PFAM: CobW/HypB/UreG, nucleotide-binding domain; TIGRFAM: urease accessory protein UreG; hydrogenase accessory protein HypB.
    
 
 0.842
Mfer_1058
Cobalamin synthesis protein P47K; COGs: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; InterPro IPR012202: IPR003495; KEGG: mth:MTH1672 hypothetical protein; PFAM: cobalamin synthesis protein P47K; SPTR: O27708 Conserved protein; PFAM: CobW/HypB/UreG, nucleotide-binding domain.
    
 
 0.842
Mfer_0627
NADH-ubiquinone oxidoreductase chain 49kDa; COGs: COG3261 Ni Fe-hydrogenase III large subunit; InterPro IPR018194: IPR001268: IPR001501: IPR001135; KEGG: tpe:Tpen_1071 NADH-ubiquinone oxidoreductase, chain 49kDa; PFAM: NADH-ubiquinone oxidoreductase chain 49kDa; nickel-dependent hydrogenase large subunit; NADH dehydrogenase (ubiquinone) 30 kDa subunit; SPTR: A1RZ40 NADH-ubiquinone oxidoreductase, chain 49kDa; PFAM: Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Nickel-dependent hydrogenase.
   
 
 0.836
rps3ae
COGs: COG1890 Ribosomal protein S3AE; InterPro IPR018281: IPR001593; KEGG: mth:MTH1593 30S ribosomal protein S3Ae; PFAM: ribosomal protein S3Ae; SPTR: O27630 30S ribosomal protein S3Ae; PFAM: Ribosomal S3Ae family; Belongs to the eukaryotic ribosomal protein eS1 family.
   
    0.790
fusA
Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...]
  
    0.764
rps28e
COGs: COG2053 Ribosomal protein S28E/S33; InterPro IPR016027: IPR000289: IPR012340; KEGG: msi:Msm_0205 30S ribosomal protein S28e; PFAM: Ribosomal protein S28e; SPTR: A5UJN2 Ribosomal protein S28e; PFAM: Ribosomal protein S28e; Belongs to the eukaryotic ribosomal protein eS28 family.
  
    0.728
rps12
SSU ribosomal protein S12P; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family.
   
  
 0.712
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.