STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0483Peptidase M50; InterPro IPR008915; KEGG: mth:MTH986 hypothetical protein; PFAM: peptidase M50; SPTR: O27067 Conserved protein; PFAM: Peptidase family M50. (195 aa)    
Predicted Functional Partners:
Mfer_0482
COGs: COG1944 conserved hypothetical protein; InterPro IPR017667: IPR003776; KEGG: mth:MTH987 hypothetical protein; PFAM: protein of unknown function DUF181; SPTR: O27068 UPF0142 protein MTH_987; TIGRFAM: methanogenesis marker protein 1; PFAM: YcaO-like family; TIGRFAM: uncharacterized domain; putative methanogenesis marker protein 1; bacteriocin biosynthesis docking scaffold, SagD family.
 
     0.897
Mfer_0484
COGs: COG0704 Phosphate uptake regulator; InterPro IPR008170; KEGG: mth:MTH1724 phosphate transport system regulator related protein; PFAM: PhoU family protein; SPTR: O27757 Phosphate transport system regulator related protein; PFAM: Sugar-specific transcriptional regulator TrmB; PhoU domain.
       0.795
Mfer_0481
PP-loop domain protein; COGs: COG1606 ATP-utilizing protein of the PP-loop superfamily; InterPro IPR005232: IPR011063: IPR014729; KEGG: msi:Msm_0482 PP family ATPase; PFAM: PP-loop domain protein; SPTR: Q2NEV1 Predicted ATP-utilizing enzyme; PFAM: ExsB; TIGRFAM: conserved hypothetical protein TIGR00268.
       0.788
Mfer_0486
Metallophosphoesterase; COGs: COG1409 phosphohydrolase; InterPro IPR004843; KEGG: mth:MTH1722 transcriptional regulator Icc related protein; PFAM: metallophosphoesterase; SPTR: O27755 Transcriptional regulator Icc related protein; PFAM: Calcineurin-like phosphoesterase.
     
 0.782
Mfer_0485
KEGG: mth:MTH1723 hypothetical protein; SPTR: O27756 Putative uncharacterized protein.
       0.773
Mfer_0845
COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006140: IPR006236: IPR016040: IPR006139: IPR 002912; KEGG: mth:MTH970 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein; PRIAM: Phosphoglycerate dehydrogenase; SPTR: O27051 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specifi [...]
     
 0.500
spt5
LSU ribosomal protein L24A; Stimulates transcription elongation; Belongs to the archaeal Spt5 family.
 
     0.494
argJ
N-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family.
     
 0.478
rtcB
Protein of unknown function UPF0027; COGs: COG1690 conserved hypothetical protein; InterPro IPR001233; KEGG: mth:MTH1597 hypothetical protein; PFAM: protein of unknown function UPF0027; SPTR: O27634 UPF0027 protein MTH_1597; PFAM: Uncharacterized protein family UPF0027; Belongs to the RtcB family.
     
 0.477
surE
5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
 
     0.446
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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