STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0533Peptidase M48 Ste24p; COGs: COG0501 Zn-dependent protease with chaperone function; InterPro IPR001915; KEGG: mth:MTH1817 heat shock protein X related protein; PFAM: peptidase M48 Ste24p; SPTR: O27845 Heat shock protein X related protein; PFAM: Peptidase family M48. (459 aa)    
Predicted Functional Partners:
Mfer_0183
Auxin Efflux Carrier; COGs: COG0679 permease; InterPro IPR004776; KEGG: mth:MTH1382 hypothetical protein; PFAM: Auxin Efflux Carrier; SPTR: O27435 Uncharacterized transporter MTH_1382; PFAM: Membrane transport protein; TIGRFAM: he Auxin Efflux Carrier (AEC) Family.
  
  
 0.791
Mfer_0534
TrkA-N domain protein; COGs: COG0569 K+ transport systems NAD-binding component; InterPro IPR003148: IPR018054: IPR016040: IPR004173: IPR 013099; KEGG: mth:MTH1258 potassium channel related protein; PFAM: TrkA-N domain protein; Ion transport 2 domain protein; 3H domain protein; SPTR: O27326 Potassium channel related protein; PFAM: Ion channel; TrkA-N domain; 3H domain.
       0.762
Mfer_0531
ATPase associated with various cellular activities AAA_5; COGs: COG0714 MoxR-like ATPase; InterPro IPR003593: IPR011704; KEGG: mth:MTH1814 hypothetical protein; PFAM: ATPase associated with various cellular activities AAA_5; SMART: AAA ATPase; SPTR: O27842 Conserved protein; PFAM: AAA domain (dynein-related subfamily).
  
  
 0.760
Mfer_1216
Membrane-bound hydrogenase subunit ehbQ; COGs: COG1707 ACT domain-containing protein; InterPro IPR015832: IPR002912; KEGG: mth:MTH1235 hypothetical protein; PFAM: amino acid-binding ACT domain protein; SPTR: O27303 Uncharacterized protein MTH_1235; PFAM: ACT domain.
  
    0.717
argD
COGs: COG4992 Ornithine/acetylornithine aminotransferase; InterPro IPR005814: IPR004636: IPR015424: IPR015422: IPR 015421; KEGG: mth:MTH1337 acetylornithine aminotransferase; PFAM: aminotransferase class-III; SPTR: O27392 Acetylornithine aminotransferase; TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: ornithine aminotransferase; 4-aminobutyrate aminotransferase, prokaryotic type; acetylornithine and succinylornithine aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
  
 
 0.709
Mfer_0599
COGs: COG1829 kinase (sugar kinase superfamily); InterPro IPR012043: IPR020568: IPR006204; KEGG: mth:MTH577 hypothetical protein; PFAM: GHMP kinase; SPTR: O26677 Conserved protein; PFAM: GHMP kinases N terminal domain.
  
    0.686
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
  
    0.660
Mfer_1106
Glutamate synthase (NADPH) GltB2 subunit; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR017896: IPR013785: IPR001450: IPR002932: IPR 017900; KEGG: mth:MTH194 glutamate synthase (NADPH), alpha subunit; PFAM: ferredoxin-dependent glutamate synthase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: O26296 Glutamate synthase (NADPH), alpha subunit; PFAM: 4Fe-4S binding domain; Conserved region in glutamate synthase; Belongs to the glutamate synthase family.
     
 0.622
Mfer_0085
COGs: COG1053 Succinate dehydrogenase/fumarate reductase flavoprotein subunit; InterPro IPR015939: IPR003953: IPR004112: IPR013027; KEGG: mth:MTH1502 succinate dehydrogenase flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; PRIAM: L-aspartate oxidase; SPTR: O27546 Succinate dehydrogenase, flavoprotein subunit; PFAM: domain; FAD binding domain; TIGRFAM: L-aspartate oxidase.
  
  
 0.599
rpl4
LSU ribosomal protein L4P; Forms part of the polypeptide exit tunnel.
  
 
 0.577
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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