STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0547COGs: COG1109 Phosphomannomutase; InterPro IPR016066: IPR005841: IPR016055: IPR005844: IPR 005845: IPR005846: IPR005843; KEGG: mth:MTH1584 phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; PRIAM: Phosphoglucosamine mutase; SPTR: Q50563 Phosphomannomutase; PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, alpha/beta/ [...] (451 aa)    
Predicted Functional Partners:
Mfer_0129
Nucleotidyl transferase; COGs: COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon); InterPro IPR011004: IPR005835: IPR001451; KEGG: mth:MTH1589 glucose-1-phosphate thymidylyltransferase-like protein; PFAM: Nucleotidyl transferase; transferase hexapeptide repeat containing protein; SPTR: O27626 Glucose-1-phosphate thymidylyltransferase homolog; PFAM: Nucleotidyl transferase; Bacterial transferase hexapeptide (three repeats); TIGRFAM: glucose-1-phosphate thym [...]
 
 0.996
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).
 
 0.959
Mfer_0286
Glucose-1-phosphate thymidylyltransferase; COGs: COG1209 dTDP-glucose pyrophosphorylase; InterPro IPR005835: IPR005907; KEGG: mth:MTH1791 glucose-1-phosphate thymidylyltransferase; PFAM: Nucleotidyl transferase; SPTR: O27819 Glucose-1-phosphate thymidylyltransferase; TIGRFAM: glucose-1-phosphate thymidylyltransferase; PFAM: Nucleotidyl transferase; TIGRFAM: glucose-1-phosphate thymidylylransferase, long form; glucose-1-phosphate thymidylyltransferase, short form.
  
 
 0.950
Mfer_1275
COGs: COG1210 UDP-glucose pyrophosphorylase; InterPro IPR005771: IPR005835; KEGG: mth:MTH634 UTP--glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; SPTR: O26731 UTP--glucose-1-phosphate uridylyltransferase; TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase.
   
 0.947
Mfer_0361
Nucleotidyl transferase; COGs: COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon); InterPro IPR011051: IPR005835: IPR013096; KEGG: mth:MTH1523 glucose-1-phosphate adenylyltransferase related protein; PFAM: Nucleotidyl transferase; Cupin 2 conserved barrel domain protein; SPTR: O27567 Glucose-1-phosphate adenylyltransferase related protein; PFAM: Nucleotidyl transferase; Mannose-6-phosphate isomerase.
 
  
 0.941
Mfer_0308
PfkB domain protein; COGs: COG0524 Sugar kinase ribokinase family; InterPro IPR002173: IPR002139: IPR011611; KEGG: mth:MTH1841 ribokinase; PFAM: PfkB domain protein; SPTR: O27869 Ribokinase; PFAM: pfkB family carbohydrate kinase; Belongs to the carbohydrate kinase PfkB family.
 
 
 0.935
Mfer_1098
PfkB domain protein; COGs: COG0524 Sugar kinase ribokinase family; InterPro IPR011611: IPR002139: IPR002173; KEGG: msi:Msm_0307 ribokinase family sugar kinase; PFAM: PfkB domain protein; SPTR: B9ACH0 Putative uncharacterized protein; PFAM: pfkB family carbohydrate kinase; Belongs to the carbohydrate kinase PfkB family.
  
 
 0.927
rpiA
Ribose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
    
 0.925
Mfer_0638
COGs: COG1260 Myo-inositol-1-phosphate synthase; InterPro IPR016040: IPR002587: IPR013021; KEGG: mth:MTH1105 hypothetical protein; PFAM: Myo-inositol-1-phosphate synthase; Myo-inositol-1-phosphate synthase GAPDH domain protein; SPTR: O27177 Conserved protein; PFAM: Myo-inositol-1-phosphate synthase.
    
 0.911
fbp
Fructose-bisphosphate aldolase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
    
 0.849
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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