STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0636Protein of unknown function DUF429; COGs: COG2410 conserved hypothetical protein; InterPro IPR018036: IPR007362; KEGG: mth:MTH1199 hypothetical protein; PFAM: Protein of unknown function DUF429; SPTR: O27267 Putative uncharacterized protein; PFAM: Protein of unknown function (DUF429). (187 aa)    
Predicted Functional Partners:
surE
5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
       0.775
ilvE
Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
       0.773
Mfer_0625
Hypothetical protein; KEGG: tpe:Tpen_1072 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein; SPTR: A1RZ41 4Fe-4S ferredoxin, iron-sulfur binding domain protein.
       0.531
Mfer_0626
NADH ubiquinone oxidoreductase 20 kDa subunit; COGs: COG3260 Ni Fe-hydrogenase III small subunit; InterPro IPR006138: IPR006137; KEGG: tpe:Tpen_1070 NADH-quinone oxidoreductase, B subunit; PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit; SPTR: A1RZ39 NADH-quinone oxidoreductase, B subunit; PFAM: NADH ubiquinone oxidoreductase, 20 Kd subunit.
       0.531
Mfer_0627
NADH-ubiquinone oxidoreductase chain 49kDa; COGs: COG3261 Ni Fe-hydrogenase III large subunit; InterPro IPR018194: IPR001268: IPR001501: IPR001135; KEGG: tpe:Tpen_1071 NADH-ubiquinone oxidoreductase, chain 49kDa; PFAM: NADH-ubiquinone oxidoreductase chain 49kDa; nickel-dependent hydrogenase large subunit; NADH dehydrogenase (ubiquinone) 30 kDa subunit; SPTR: A1RZ40 NADH-ubiquinone oxidoreductase, chain 49kDa; PFAM: Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Nickel-dependent hydrogenase.
       0.531
Mfer_0628
COGs: COG1005 NADH:ubiquinone oxidoreductase subunit 1 (chain H); InterPro IPR001694; KEGG: tpe:Tpen_1073 respiratory-chain NADH dehydrogenase, subunit 1; PFAM: respiratory-chain NADH dehydrogenase subunit 1; SPTR: A1RZ42 Respiratory-chain NADH dehydrogenase, subunit 1; PFAM: NADH dehydrogenase.
       0.531
Mfer_0629
4Fe-4S ferredoxin iron-sulfur binding domain protein; COGs: COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I); InterPro IPR017900: IPR017896: IPR001450; KEGG: tpe:Tpen_1072 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: A1RZ41 4Fe-4S ferredoxin, iron-sulfur binding domain protein; PFAM: 4Fe-4S binding domain.
       0.531
Mfer_0630
KEGG: tpe:Tpen_1074 hypothetical protein; SPTR: A1RZ43 Putative uncharacterized protein.
       0.531
Mfer_0631
KEGG: pnu:Pnuc_1671 hypothetical protein; SPTR: A4SZH0 Putative uncharacterized protein.
       0.531
Mfer_0632
NADH/Ubiquinone/plastoquinone (complex I); COGs: COG1009 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter MnhA subunit; InterPro IPR003916: IPR001516: IPR001750; KEGG: tpe:Tpen_1076 proton-translocating NADH-quinone oxidoreductase, chain L; PFAM: NADH/Ubiquinone/plastoquinone (complex I); NADH-Ubiquinone oxidoreductase (complex I) chain 5/L domain protein; SPTR: A1RZ45 Proton-translocating NADH-quinone oxidoreductase, chain L; PFAM: NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; NADH-Ubiquinone/plastoquinone (complex I), various chains.
       0.531
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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