STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0639COGs: COG1237 Metal-dependent hydrolase of the beta-lactamase superfamily II; KEGG: ctc:CTC02162 metal dependent hydrolase; SPTR: A5KXJ4 Putative uncharacterized protein; PFAM: Metallo-beta-lactamase superfamily. (262 aa)    
Predicted Functional Partners:
Mfer_0557
COGs: COG1237 Metal-dependent hydrolase of the beta-lactamase superfamily II; KEGG: mka:MK1323 beta-lactamase superfamily hydrolase; SPTR: Q8TVR5 Metal-dependent hydrolase of the beta-lactamase superfamily; PFAM: Metallo-beta-lactamase superfamily.
  
  
 
0.924
mptE
Protein of unknown function DUF115; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family.
    
  0.903
Mfer_0638
COGs: COG1260 Myo-inositol-1-phosphate synthase; InterPro IPR016040: IPR002587: IPR013021; KEGG: mth:MTH1105 hypothetical protein; PFAM: Myo-inositol-1-phosphate synthase; Myo-inositol-1-phosphate synthase GAPDH domain protein; SPTR: O27177 Conserved protein; PFAM: Myo-inositol-1-phosphate synthase.
       0.757
Mfer_0640
Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
       0.581
Mfer_0793
Protein of unknown function DUF134; COGs: COG1342 DNA-binding protein; InterPro IPR002852; KEGG: mth:MTH1178 hypothetical protein; PFAM: protein of unknown function DUF134; SPTR: O27246 UPF0251 protein MTH_1178; PFAM: Protein of unknown function DUF134; Belongs to the UPF0251 family.
 
     0.409
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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