STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_06985-carboxymethyl-2-hydroxymuconateDelta- isomerase; COGs: COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1 7-dioic acid hydratase (catechol pathway); InterPro IPR011234: IPR002529; KEGG: mth:MTH1507 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase; PFAM: fumarylacetoacetate (FAA) hydrolase; PRIAM: 5-carboxymethyl-2-hydroxymuconate Delta-isomerase; SPTR: O27551 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase; PFAM: Fumarylacetoacetate (FAA) hydrolase family. (256 aa)    
Predicted Functional Partners:
Mfer_0494
Amidohydrolase; COGs: COG1228 Imidazolonepropionase and related amidohydrolase; InterPro IPR011059: IPR006680; KEGG: mth:MTH1534 aryldialkylphosphatase related protein; PFAM: amidohydrolase; SPTR: O27577 Aryldialkylphosphatase related protein; PFAM: Amidohydrolase family.
    
 0.912
dphB
Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
  
  
 0.792
Mfer_1155
Pre-mRNA processing ribonucleoprotein, binding domain protein; COGs: COG1498 Protein implicated in ribosomal biogenesis Nop56p homolog; InterPro IPR012976: IPR002687; KEGG: mth:MTH1214 pre-mRNA splicing protein PRP31; PFAM: Pre-mRNA processing ribonucleoprotein, binding domain protein; NOSIC domain protein; SPTR: O27282 Pre-mRNA splicing protein PRP31; PFAM: Putative snoRNA binding domain; NOSIC (NUC001) domain.
    
 0.782
Mfer_0699
Methyltransferase type 11; COGs: COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis; InterPro IPR013216; KEGG: mth:MTH1876 hypothetical protein; PFAM: Methyltransferase type 11; SPTR: O27904 Conserved protein; PFAM: Methyltransferase domain.
       0.781
Mfer_0693
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR016160: IPR016162: IPR016161: IPR015590; KEGG: mth:MTH978 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: O27059 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family.
 
 
 0.748
Mfer_0702
Fumarase beta subunit; COGs: COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I C-terminal domain; InterPro IPR004647; KEGG: mst:Msp_0791 fumarate hydratase; PFAM: Fe-S type hydro-lyase tartrate/fumarate beta region; PRIAM: Fumarate hydratase; SPTR: Q2NG69 Fumarate hydratase; TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; PFAM: Fumarase C-terminus; TIGRFAM: hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region.
       0.649
Mfer_0701
KEGG: mth:MTH1911 hypothetical protein; SPTR: O27933 Putative uncharacterized protein.
       0.636
Mfer_0703
KEGG: mth:MTH1908 hypothetical protein; SPTR: O27930 Putative uncharacterized protein.
       0.623
valS
valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
  
    0.600
Mfer_0845
COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006140: IPR006236: IPR016040: IPR006139: IPR 002912; KEGG: mth:MTH970 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein; PRIAM: Phosphoglycerate dehydrogenase; SPTR: O27051 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specifi [...]
     
 0.578
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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