STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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[Homology]
Score
mrtBMethyl-coenzyme M reductase, beta subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (443 aa)    
Predicted Functional Partners:
mrtG
Methyl-coenzyme M reductase, gamma subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
  
 0.999
mrtA
Methyl-coenzyme M reductase, alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
  
 0.999
Mfer_0784
Methyl-coenzyme M reductase, alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
  
 0.994
Mfer_0785
COGs: COG4057 Methyl coenzyme M reductase gamma subunit; InterPro IPR003178: IPR009024; KEGG: mth:MTH1165 methyl coenzyme M reductase I, gamma subunit; PFAM: Methyl-coenzyme M reductase, gamma subunit; PRIAM: Coenzyme-B sulfoethylthiotransferase; SPTR: P12973 Methyl-coenzyme M reductase subunit gamma; TIGRFAM: methyl-coenzyme M reductase, gamma subunit; PFAM: Methyl-coenzyme M reductase gamma subunit; TIGRFAM: methyl-coenzyme M reductase, gamma subunit.
  
 0.994
mrtD
COGs: COG4055 Methyl coenzyme M reductase subunit D; InterPro IPR003901; KEGG: mth:MTH1131 methyl coenzyme M reductase II, D protein; PFAM: Methyl-coenzyme M reductase, protein D; SPTR: Q49172 Methyl-coenzyme M reductase II operon protein D; TIGRFAM: methyl-coenzyme M reductase operon protein D; PFAM: Methyl-coenzyme M reductase operon protein D; TIGRFAM: methyl-coenzyme M reductase operon protein D.
  
  
 0.950
Mfer_0788
COGs: COG4054 Methyl coenzyme M reductase beta subunit; InterPro IPR003179: IPR008924: IPR009024; KEGG: mth:MTH1168 methyl coenzyme M reductase I, beta subunit; PFAM: Methyl-coenzyme M reductase, beta subunit; PRIAM: Coenzyme-B sulfoethylthiotransferase; SPTR: P12972 Methyl-coenzyme M reductase subunit beta; TIGRFAM: methyl-coenzyme M reductase, beta subunit; PFAM: Methyl-coenzyme M reductase beta subunit, C-terminal domain; Methyl-coenzyme M reductase beta subunit, N-terminal domain; TIGRFAM: methyl-coenzyme M reductase, beta subunit.
     
 
0.900
mtrH
Tetrahydromethanopterin S-methyltransferase, subunit H; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
  
 
 0.797
mtrG
Tetrahydromethanopterin S-methyltransferase, subunit G; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
  
 
 0.795
Mfer_0727
COGs: COG1908 Coenzyme F420-reducing hydrogenase delta subunit; InterPro IPR003813; KEGG: mth:MTH1136 methyl viologen-reducing hydrogenase, delta subunit; PFAM: methyl-viologen-reducing hydrogenase delta subunit; SPTR: Q50781 F420-non-reducing hydrogenase iron-sulfur subunit D; PFAM: Methyl-viologen-reducing hydrogenase, delta subunit.
  
 
  0.793
mtrB
Tetrahydromethanopterin S-methyltransferase, subunit B; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
  
 
 0.789
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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