STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rnzRNAse Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (328 aa)    
Predicted Functional Partners:
Mfer_0745
COGs: COG3264 Small-conductance mechanosensitive channel; InterPro IPR010920: IPR011014: IPR011066: IPR006685; KEGG: mth:MTH1830 hypothetical protein; PFAM: MscS Mechanosensitive ion channel; SPTR: O27858 Conserved protein; PFAM: Mechanosensitive ion channel.
  
    0.874
Mfer_0746
COGs: COG3764 Sortase (surface protein transpeptidase); InterPro IPR005754; KEGG: mth:MTH1829 hypothetical protein; PFAM: peptidase C60 sortase A and B; SPTR: O27857 Conserved protein; PFAM: Sortase family; TIGRFAM: LPXTG-site transpeptidase (sortase) family protein.
       0.791
nadA
Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
     
 0.785
Mfer_0748
LOR/SDH bifunctional protein; COGs: COG1915 conserved hypothetical protein; InterPro IPR005239: IPR007545; KEGG: mka:MK0866 hypothetical protein; PFAM: LOR/SDH bifunctional protein conserved domain protein; SPTR: Q8TX14 Uncharacterized protein MK0866; PFAM: LOR/SDH bifunctional enzyme conserved region; TIGRFAM: conserved hypothetical protein TIGR00300.
       0.708
Mfer_0743
Nicotinate-nucleotide pyrophosphorylase (carboxylating); Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
     
 0.663
rrp41
Ribosomal RNA-processing protein RRP41/SKI6; Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
  
  
 0.654
valS
valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
  
  
 0.615
Mfer_0391
KH-domain/beta-lactamase-domain protein; COGs: COG1782 metal-dependent RNase consists of a metallo-beta-lactamase domain and an RNA-binding KH domain; InterPro IPR004088: IPR004087: IPR018117: IPR019975: IPR 009019: IPR018111: IPR011108; KEGG: mth:MTH1203 cleavage and polyadenylation specificity factor; PFAM: RNA-metabolising metallo-beta-lactamase; K Homology, type 1, subgroup; SMART: KH domain protein; SPTR: O27271 Cleavage and polyadenylation specificity factor; TIGRFAM: KH-domain/beta-lactamase-domain protein; PFAM: Metallo-beta-lactamase superfamily; RNA-metabolising metallo-beta- [...]
      
 0.589
fbp
Fructose-bisphosphate aldolase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
       0.564
hisS
COGs: COG0124 Histidyl-tRNA synthetase; InterPro IPR004516: IPR006195: IPR004154: IPR002314: IPR 015807; KEGG: mth:MTH244 histidyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; PRIAM: Histidine--tRNA ligase; SPTR: O26346 Histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: ATP phosphoribosyltransferase, regulatory subunit; histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
 
 0.555
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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