STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0745COGs: COG3264 Small-conductance mechanosensitive channel; InterPro IPR010920: IPR011014: IPR011066: IPR006685; KEGG: mth:MTH1830 hypothetical protein; PFAM: MscS Mechanosensitive ion channel; SPTR: O27858 Conserved protein; PFAM: Mechanosensitive ion channel. (254 aa)    
Predicted Functional Partners:
rnz
RNAse Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family.
  
    0.874
Mfer_0471
NMD3 family protein; COGs: COG1499 NMD protein affecting ribosome stability and mRNA decay; InterPro IPR007064; KEGG: mth:MTH1768 hypothetical protein; PFAM: NMD3 family protein; SPTR: O27796 Conserved protein; PFAM: NMD3 family.
   
    0.799
Mfer_0746
COGs: COG3764 Sortase (surface protein transpeptidase); InterPro IPR005754; KEGG: mth:MTH1829 hypothetical protein; PFAM: peptidase C60 sortase A and B; SPTR: O27857 Conserved protein; PFAM: Sortase family; TIGRFAM: LPXTG-site transpeptidase (sortase) family protein.
       0.791
nadA
Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
       0.775
Mfer_0748
LOR/SDH bifunctional protein; COGs: COG1915 conserved hypothetical protein; InterPro IPR005239: IPR007545; KEGG: mka:MK0866 hypothetical protein; PFAM: LOR/SDH bifunctional protein conserved domain protein; SPTR: Q8TX14 Uncharacterized protein MK0866; PFAM: LOR/SDH bifunctional enzyme conserved region; TIGRFAM: conserved hypothetical protein TIGR00300.
 
     0.739
Mfer_0743
Nicotinate-nucleotide pyrophosphorylase (carboxylating); Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
       0.622
fbp
Fructose-bisphosphate aldolase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
       0.564
Mfer_1261
TrkA-N domain protein; COGs: COG0569 K+ transport systems NAD-binding component; InterPro IPR016040: IPR003148: IPR006037: IPR006036; KEGG: mth:MTH1265 trk system potassium uptake protein TrkA; PFAM: TrkA-N domain protein; TrkA-C domain protein; SPTR: O27333 Trk system potassium uptake protein trkA homolog; PFAM: TrkA-N domain; TrkA-C domain.
 
   
 0.522
Mfer_0845
COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006140: IPR006236: IPR016040: IPR006139: IPR 002912; KEGG: mth:MTH970 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein; PRIAM: Phosphoglycerate dehydrogenase; SPTR: O27051 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specifi [...]
  
  
 0.517
Mfer_1088
Isochorismatase hydrolase; COGs: COG1335 Amidase related to nicotinamidase; InterPro IPR000868: IPR003881; KEGG: dka:DKAM_1450 isochorismatase hydrolase; PFAM: isochorismatase hydrolase; SPTR: B8D6P5 Isochorismatase hydrolase; PFAM: Isochorismatase family.
  
  
 0.496
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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