STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadAQuinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (304 aa)    
Predicted Functional Partners:
Mfer_0743
Nicotinate-nucleotide pyrophosphorylase (carboxylating); Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
 
 0.999
nadX
Aspartate dehydrogenase; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
    
 0.946
Mfer_0085
COGs: COG1053 Succinate dehydrogenase/fumarate reductase flavoprotein subunit; InterPro IPR015939: IPR003953: IPR004112: IPR013027; KEGG: mth:MTH1502 succinate dehydrogenase flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; PRIAM: L-aspartate oxidase; SPTR: O27546 Succinate dehydrogenase, flavoprotein subunit; PFAM: domain; FAD binding domain; TIGRFAM: L-aspartate oxidase.
   
 0.803
rnz
RNAse Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family.
     
 0.785
Mfer_0745
COGs: COG3264 Small-conductance mechanosensitive channel; InterPro IPR010920: IPR011014: IPR011066: IPR006685; KEGG: mth:MTH1830 hypothetical protein; PFAM: MscS Mechanosensitive ion channel; SPTR: O27858 Conserved protein; PFAM: Mechanosensitive ion channel.
       0.775
Mfer_0746
COGs: COG3764 Sortase (surface protein transpeptidase); InterPro IPR005754; KEGG: mth:MTH1829 hypothetical protein; PFAM: peptidase C60 sortase A and B; SPTR: O27857 Conserved protein; PFAM: Sortase family; TIGRFAM: LPXTG-site transpeptidase (sortase) family protein.
       0.750
Mfer_0748
LOR/SDH bifunctional protein; COGs: COG1915 conserved hypothetical protein; InterPro IPR005239: IPR007545; KEGG: mka:MK0866 hypothetical protein; PFAM: LOR/SDH bifunctional protein conserved domain protein; SPTR: Q8TX14 Uncharacterized protein MK0866; PFAM: LOR/SDH bifunctional enzyme conserved region; TIGRFAM: conserved hypothetical protein TIGR00300.
       0.732
dapA
Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
 
  
 0.688
nadE
NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
  
  
 0.656
fbp
Fructose-bisphosphate aldolase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
       0.586
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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