STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rnhBRNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (200 aa)    
Predicted Functional Partners:
pcn
Monomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
  
 
 0.953
priS
DNA primase, small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...]
 
  
 0.933
Mfer_0221
COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR006134; KEGG: mth:MTH208 DNA-dependent DNA polymerase family B protein; PFAM: DNA polymerase B region; SPTR: O26310 DNA-dependent DNA polymerase family B (PolB2); PFAM: DNA polymerase family B.
   
 
 0.905
Mfer_0904
COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR017964: IPR017966: IPR012337: IPR006133: IPR 006134: IPR006172; KEGG: mth:MTH1208 DNA-dependent DNA polymerase family B protein; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; PRIAM: DNA-directed DNA polymerase; SMART: DNA-directed DNA polymerase B; SPTR: O27276 DNA polymerase; PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain.
   
 
 0.905
priL
DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
   
  
 0.836
Mfer_0255
Thymidylate synthase, methanogen type; COGs: COG0207 Thymidylate synthase; InterPro IPR000398: IPR014620; KEGG: mth:MTH774 thymidylate synthase; PFAM: thymidylate synthase; SPTR: P80305 Putative thymidylate synthase; TIGRFAM: thymidylate synthase, methanogen type; PFAM: Thymidylate synthase; TIGRFAM: thymidylate synthase, methanogen type.
  
 
 0.834
Mfer_0629
4Fe-4S ferredoxin iron-sulfur binding domain protein; COGs: COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I); InterPro IPR017900: IPR017896: IPR001450; KEGG: tpe:Tpen_1072 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: A1RZ41 4Fe-4S ferredoxin, iron-sulfur binding domain protein; PFAM: 4Fe-4S binding domain.
  
 
 0.834
Mfer_0030
COGs: COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; InterPro IPR020845: IPR000169: IPR000873; KEGG: mth:MTH657 AMP-binding domain protein; PFAM: AMP-dependent synthetase and ligase; SPTR: O26753 Long-chain-fatty-acid-CoA ligase; PFAM: AMP-binding enzyme.
  
 
 0.818
Mfer_0915
KEGG: mth:MTH1025 hypothetical protein; SPTR: O27104 Putative uncharacterized protein.
       0.802
Mfer_0916
Rod shape-determining protein MreB; COGs: COG1077 Actin-like ATPase involved in cell morphogenesis; InterPro IPR004753; KEGG: mth:MTH1024 rod shape-determining protein MreB; PFAM: cell shape determining protein MreB/Mrl; SPTR: O27103 Rod shape-determining protein; PFAM: MreB/Mbl protein; TIGRFAM: cell shape determining protein, MreB/Mrl family.
       0.802
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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