STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_1032COGs: COG3259 Coenzyme F420-reducing hydrogenase alpha subunit; InterPro IPR001501: IPR018194: IPR017682; KEGG: mth:MTH1300 coenzyme F420-reducing hydrogenase, alpha subunit; PFAM: nickel-dependent hydrogenase large subunit; SPTR: P19496 Coenzyme F420 hydrogenase subunit alpha; TIGRFAM: coenzyme F420 hydrogenase, subunit alpha; PFAM: Nickel-dependent hydrogenase; TIGRFAM: coenzyme F420 hydrogenase, subunit alpha; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (408 aa)    
Predicted Functional Partners:
hypA
Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.999
Mfer_0402
Hydrogenase accessory protein HypB; COGs: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; InterPro IPR012202: IPR004392: IPR003495; KEGG: mth:MTH782 hydrogenase expression/formation protein HypB; PFAM: cobalamin synthesis protein P47K; SPTR: O26875 Hydrogenase expression/formation protein HypB; TIGRFAM: hydrogenase accessory protein HypB; PFAM: CobW/HypB/UreG, nucleotide-binding domain; TIGRFAM: urease accessory protein UreG; hydrogenase accessory protein HypB.
  
  
 0.999
ftr
Formylmethanofuran-tetrahydromethanopterin formyltransferase; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family.
      
 0.999
mtd
Methylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
     
 0.999
Mfer_1034
COGs: COG1941 Coenzyme F420-reducing hydrogenase gamma subunit; InterPro IPR017896: IPR006137: IPR001450: IPR017900: IPR 017681; KEGG: mth:MTH1298 coenzyme F420-reducing hydrogenase, gamma subunit; PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit; 4Fe-4S ferredoxin iron-sulfur binding domain protein; PRIAM: Coenzyme F420 hydrogenase; SPTR: P19498 Coenzyme F420 hydrogenase subunit gamma; TIGRFAM: coenzyme F420 hydrogenase, subunit gamma; PFAM: NADH ubiquinone oxidoreductase, 20 Kd subunit; TIGRFAM: coenzyme F420 hydrogenase, subunit gamma.
 
 0.999
Mfer_1035
COGs: COG1035 Coenzyme F420-reducing hydrogenase beta subunit; InterPro IPR007516: IPR007525: IPR017679; KEGG: mth:MTH1297 coenzyme F420-reducing hydrogenase subunit beta; PFAM: coenzyme F420 hydrogenase/dehydrogenase beta subunit domain protein; SPTR: P19499 Coenzyme F420 hydrogenase subunit beta; TIGRFAM: coenzyme F420 hydrogenase, subunit beta; PFAM: Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; TIGRFAM: coenzyme F420 hydrogenase, subunit beta.
 
 0.999
Mfer_1230
(NiFe) hydrogenase maturation protein HypF; COGs: COG0068 Hydrogenase maturation factor; InterPro IPR017945: IPR001792: IPR006070: IPR004421: IPR 017968: IPR011125; KEGG: mth:MTH1287 transcriptional regulator HypF-like protein; PFAM: SUA5/yciO/yrdC domain; acylphosphatase; zinc finger HypF domain protein; SPTR: O27348 Transcriptional regulator HypF homolog; TIGRFAM: [NiFe] hydrogenase maturation protein HypF; PFAM: HypF finger; yrdC domain; Acylphosphatase; TIGRFAM: [NiFe] hydrogenase maturation protein HypF.
 
 
 
 0.999
Mfer_1033
Coenzyme F420-reducing hydrogenase, delta subunit; COGs: COG0680 Ni Fe-hydrogenase maturation factor; InterPro IPR000671: IPR004411; KEGG: mth:MTH1299 coenzyme F420-reducing hydrogenase, delta subunit; PFAM: peptidase M52 hydrogen uptake protein; SPTR: P19497 Coenzyme F420 hydrogenase subunit delta; TIGRFAM: coenzyme F420-reducing hydrogenase delta subunit; hydrogenase maturation protease; PFAM: Hydrogenase maturation protease; TIGRFAM: coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); hydrogenase maturation protease.
 
 0.997
Mfer_1105
COGs: COG1035 Coenzyme F420-reducing hydrogenase beta subunit; InterPro IPR017896: IPR007525: IPR001450: IPR007516: IPR 017900; KEGG: mth:MTH193 coenzyme F420-reducing hydrogenase, beta subunit-like protein; PFAM: coenzyme F420 hydrogenase/dehydrogenase beta subunit domain protein; 4Fe-4S ferredoxin iron-sulfur binding domain protein; PRIAM: Coenzyme F420 hydrogenase; SPTR: O26295 Coenzyme F420-reducing hydrogenase, beta subunit homolog; PFAM: Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus.
  
 0.987
Mfer_0728
COGs: COG1941 Coenzyme F420-reducing hydrogenase gamma subunit; InterPro IPR006137; KEGG: mth:MTH1135 methyl viologen-reducing hydrogenase, gamma subunit; PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit; SPTR: Q50782 F420-non-reducing hydrogenase subunit G; PFAM: NADH ubiquinone oxidoreductase, 20 Kd subunit.
 
 
 0.983
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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