STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_1055tRNA-archaeosine synthase; COGs: COG1549 Queuine tRNA-ribosyltransferase contain PUA domain; InterPro IPR002478: IPR015947: IPR004521; KEGG: mth:MTH1665 hypothetical protein; PFAM: PUA domain containing protein; SMART: PUA domain containing protein; SPTR: O27701 Conserved protein; PFAM: PUA domain; TIGRFAM: uncharacterized domain 2. (302 aa)    
Predicted Functional Partners:
tgtA
Archaeosine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family.
 
  
0.815
Mfer_0272
Radical SAM domain protein; COGs: COG1244 Fe-S oxidoreductase; InterPro IPR002223: IPR007197: IPR006638: IPR005909; KEGG: mth:MTH1751 hypothetical protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: O27783 Conserved protein; TIGRFAM: conserved hypothetical protein TIGR01210.
 
     0.788
Mfer_1056
Protein of unknown function DUF129; COGs: COG4071 conserved hypothetical protein; InterPro IPR012030: IPR002847; KEGG: mth:MTH1670 hypothetical protein; PFAM: protein of unknown function DUF129; SPTR: O27706 Conserved protein; PFAM: F420-0:Gamma-glutamyl ligase.
       0.781
Mfer_1057
COGs: COG2000 Fe-S protein; InterPro IPR007202; KEGG: mth:MTH1671 hypothetical protein; PFAM: Fe-S cluster domain protein; SPTR: O27707 Conserved protein; PFAM: Putative Fe-S cluster.
       0.773
Mfer_1058
Cobalamin synthesis protein P47K; COGs: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; InterPro IPR012202: IPR003495; KEGG: mth:MTH1672 hypothetical protein; PFAM: cobalamin synthesis protein P47K; SPTR: O27708 Conserved protein; PFAM: CobW/HypB/UreG, nucleotide-binding domain.
       0.773
Mfer_1059
ABC transporter related protein; COGs: COG1136 ABC-type antimicrobial peptide transport system ATPase component; InterPro IPR003439: IPR003593: IPR017871; KEGG: mth:MTH1673 sn-glycerol-3-phosphate transport ATP-binding protein; PFAM: ABC transporter related; SMART: AAA ATPase; SPTR: O27709 SN-glycerol-3-phosphate transport ATP-binding protein; PFAM: ABC transporter.
       0.773
Mfer_1060
Phosphosulfolactate synthase; COGs: COG1809 conserved hypothetical protein; InterPro IPR003830: IPR013785; KEGG: mth:MTH1674 hypothetical protein; PFAM: (2R)-phospho-3-sulfolactate synthase ComA; PRIAM: Phosphosulfolactate synthase; SPTR: O27710 Phosphosulfolactate synthase; PFAM: (2R)-phospho-3-sulfolactate synthase (ComA); TIGRFAM: phosphosulfolactate synthase.
       0.773
rpl40e
KEGG: mth:MTH553 50S ribosomal protein L40e; SPTR: O26653 50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family.
  
     0.686
Mfer_0471
NMD3 family protein; COGs: COG1499 NMD protein affecting ribosome stability and mRNA decay; InterPro IPR007064; KEGG: mth:MTH1768 hypothetical protein; PFAM: NMD3 family protein; SPTR: O27796 Conserved protein; PFAM: NMD3 family.
  
     0.667
Mfer_0099
COGs: COG2150 regulator of amino acid metabolism contains ACT domain; InterPro IPR002912: IPR014424; KEGG: mth:MTH1654 hypothetical protein; PFAM: amino acid-binding ACT domain protein; SPTR: O27691 Putative uncharacterized protein; PFAM: ACT domain.
 
     0.663
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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