Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Mfer_1069COGs: COG3764 Sortase (surface protein transpeptidase); InterPro IPR005754: IPR000215; KEGG: mth:MTH1030 hypothetical protein; PFAM: peptidase C60 sortase A and B; SPTR: O27109 Putative uncharacterized protein; TIGRFAM: sortase family protein; PFAM: Sortase family; TIGRFAM: LPXTG-site transpeptidase (sortase) family protein. (241 aa)    
Predicted Functional Partners:
Mfer_1071
InterPro IPR005242; KEGG: mth:MTH378 hypothetical protein; PFAM: conserved hypothetical protein; SPTR: O26478 UPF0104 membrane protein MTH_378; PFAM: Uncharacterised protein family (UPF0104); TIGRFAM: conserved hypothetical protein.
 
     0.621
mptD
Protein of unknown function DUF372; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family.
       0.581
Mfer_1070
COGs: COG0463 Glycosyltransferase involved in cell wall biogenesis; InterPro IPR001173; KEGG: mth:MTH377 dolichyl-phosphate mannose synthase related protein; PFAM: glycosyl transferase family 2; SPTR: O26477 Dolichyl-phosphate mannose synthase related protein; PFAM: Glycosyl transferase family 2.
       0.562
Mfer_1072
COGs: COG1216 glycosyltransferase; InterPro IPR001173; KEGG: pab:PAB0795 rhamnosyl transferase related protein; PFAM: glycosyl transferase family 2; SPTR: Q9UZG0 Putative uncharacterized protein; PFAM: Glycosyl transferase family 2.
       0.562
Mfer_1073
COGs: COG0438 Glycosyltransferase; InterPro IPR001296; KEGG: siy:YG5714_0617 glycosyl transferase group 1; PFAM: glycosyl transferase group 1; SPTR: C3NBC8 Glycosyl transferase group 1; PFAM: Glycosyl transferases group 1.
       0.562
Mfer_1074
Glycosyl transferase family 2; InterPro IPR001173; KEGG: mst:Msp_0062 hypothetical protein; PFAM: glycosyl transferase family 2; SPTR: Q2NIB8 Putative uncharacterized protein; PFAM: Glycosyl transferase family 2.
       0.562
Mfer_1075
COGs: COG0438 Glycosyltransferase; InterPro IPR001296; KEGG: mmq:MmarC5_1307 glycosyl transferase, group 1; PFAM: glycosyl transferase group 1; SPTR: A4FZH1 Glycosyl transferase, group 1; PFAM: Glycosyl transferases group 1.
       0.537
Mfer_0340
Mur ligase middle domain protein; COGs: COG0771 UDP-N-acetylmuramoylalanine-D-glutamate ligase; InterPro IPR013221: IPR006115: IPR016040; KEGG: mth:MTH532 UDP-N-acetylmuramyl tripeptide synthetase related protein; PFAM: Mur ligase middle domain protein; 6-phosphogluconate dehydrogenase NAD-binding; SPTR: O26632 UDP-N-acetylmuramyl tripeptide synthetase related protein; PFAM: Mur ligase middle domain.
  
     0.492
Mfer_0217
Protein of unknown function DUF1002; COGs: COG4086 secreted protein; InterPro IPR009343; KEGG: mth:MTH1038 hypothetical protein; PFAM: protein of unknown function DUF1002; SPTR: O27117 Conserved protein; PFAM: Protein of unknown function (DUF1002).
  
     0.476
Mfer_0336
Mur ligase middle domain protein; COGs: COG0771 UDP-N-acetylmuramoylalanine-D-glutamate ligase; InterPro IPR018109: IPR013221: IPR004101: IPR016040; KEGG: mth:MTH530 UDP-N-acetylmuramyl tripeptide synthetase related protein; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; SPTR: O26630 UDP-N-acetylmuramyl tripeptide synthetase related protein; PFAM: Mur ligase family, glutamate ligase domain; Mur ligase middle domain.
  
     0.470
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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