STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_1140CRISPR-associated protein Cas6; COGs: COG1583 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily); InterPro IPR002743: IPR020592: IPR010156; KEGG: mst:Msp_0418 hypothetical protein; PFAM: protein of unknown function DUF57; SPTR: Q2NH84 Putative uncharacterized protein; TIGRFAM: CRISPR-associated protein Cas6; PFAM: CRISPR associated protein Cas6; TIGRFAM: CRISPR-associated endoribonuclease Cas6. (237 aa)    
Predicted Functional Partners:
Mfer_1139
Hypothetical protein; KEGG: mpu:MYPU_6780 restriction-modification enzyme subunit M1; SPTR: Q98QD3 RESTRICTION MODIFICATION ENZYME SUBUNIT M2.
       0.773
cas2
CRISPR-associated protein, Cas2 family; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
   
 0.767
Mfer_1138
KEGG: tko:TK0675 hypothetical protein; SPTR: C2A1U7 Putative uncharacterized protein.
       0.655
Mfer_1101
Radical SAM domain protein; COGs: COG1032 Fe-S oxidoreductase; InterPro IPR007197: IPR006638; KEGG: mfe:Mefer_0266 radical SAM domain protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: B5IGV6 Radical SAM domain protein; PFAM: Radical SAM superfamily.
 
     0.498
Mfer_1141
Hypothetical protein; InterPro IPR008947; KEGG: mth:MTH53 hypothetical protein; SPTR: O26159 Putative uncharacterized protein; PFAM: Zinc dependent phospholipase C.
       0.432
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.