STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_1176PP-loop domain protein; COGs: COG0037 ATPase of the PP-loop superfamily protein implicated in cell cycle control; InterPro IPR012089: IPR014729: IPR011063; KEGG: pab:PAB1092 hypothetical protein; PFAM: PP-loop domain protein; SPTR: Q9UY42 Predicted ATPase of the PP-loop superfamilyl; PFAM: PP-loop family; TIGRFAM: conserved hypothetical protein TIGR00269. (297 aa)    
Predicted Functional Partners:
Mfer_1177
Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; COGs: COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase; InterPro IPR007085: IPR003382: IPR005252; KEGG: mth:MTH1216 pantothenate metabolism flavoprotein; PFAM: DNA/pantothenate metabolism flavoprotein domain protein; flavoprotein; SPTR: O27284 Pantothenate metabolism flavoprotein; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; PFAM: DNA / pantothenate metabolism flavoprotein; Flavoprotein; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothen [...]
  
  
 0.821
Mfer_0963
COGs: COG2519 tRNA(1-methyladenosine) methyltransferase and related methyltransferase; InterPro IPR014816; KEGG: mth:MTH1414 protein-L-isoaspartate methyltransferase-like protein; PFAM: tRNA methyltransferase complex GCD14 subunit; PRIAM: tRNA (adenine-N(1)-)-methyltransferase; SPTR: O27465 Protein-L-isoaspartate methyltransferase homolog; PFAM: tRNA methyltransferase complex GCD14 subunit.
 
  
 0.800
Mfer_1178
COGs: COG0195 Transcription elongation factor; InterPro IPR004088: IPR009019; KEGG: mth:MTH1217 transcription elongation factor NusA-like protein; SPTR: O27285 Putative uncharacterized protein; PFAM: KH domain.
       0.774
Mfer_1179
KEGG: mth:MTH1218 hypothetical protein; SPTR: O27286 Putative uncharacterized protein.
       0.648
Mfer_1180
KEGG: mth:MTH1219 hypothetical protein; SPTR: O27287 Putative uncharacterized protein.
       0.639
Mfer_1183
Protein of unknown function Met10; COGs: COG2520 methyltransferase; InterPro IPR003402; KEGG: mth:MTH1873 met-10+ protein; PFAM: protein of unknown function Met10; SPTR: O27901 Met-10+ protein; PFAM: Met-10+ like-protein.
  
  
 0.587
Mfer_0212
COGs: COG0381 UDP-N-acetylglucosamine 2-epimerase; InterPro IPR003331; KEGG: mth:MTH837 UDP-N-acetylglucosamine 2-epimerase; PFAM: UDP-N-acetylglucosamine 2-epimerase; PRIAM: UDP-N-acetylglucosamine 2-epimerase; SPTR: O26925 UDP-N-acetylglucosamine 2-epimerase; TIGRFAM: UDP-N-acetylglucosamine 2-epimerase; PFAM: UDP-N-acetylglucosamine 2-epimerase; TIGRFAM: UDP-N-acetylglucosamine 2-epimerase.
  
  
 0.579
truD
tRNA pseudouridine synthase D TruD; Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family.
 
 
 0.566
rlmE
23S rRNA Um-2552 2'-O-methyltransferase; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
  
  
 0.516
Mfer_0689
Histone acetyltransferase, ELP3 family; COGs: COG1243 Histone acetyltransferase; InterPro IPR005910: IPR013785: IPR016181: IPR007197: IPR 000182: IPR006638; KEGG: mth:MTH817 hypothetical protein; PFAM: Radical SAM domain protein; GCN5-related N-acetyltransferase; PRIAM: Histone acetyltransferase; SMART: Elongator protein 3/MiaB/NifB; SPTR: O26908 Conserved protein; TIGRFAM: histone acetyltransferase, ELP3 family; PFAM: Acetyltransferase (GNAT) family; Radical SAM superfamily; TIGRFAM: histone acetyltransferase, ELP3 family.
   
 
 0.496
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.