STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_1191COGs: COG1855 ATPase (PilT family); InterPro IPR004088: IPR009019: IPR002716: IPR018111: IPR 006596: IPR003593: IPR004087; KEGG: mth:MTH246 ATPase; PFAM: PilT protein domain protein; K Homology, type 1, subgroup; SMART: Nucleotide binding protein PINc; AAA ATPase; KH domain protein; SPTR: O26348 Twitching mobility (PilT) related protein; PFAM: KH domain; Type II/IV secretion system protein; PIN domain. (605 aa)    
Predicted Functional Partners:
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
       0.880
hisS
COGs: COG0124 Histidyl-tRNA synthetase; InterPro IPR004516: IPR006195: IPR004154: IPR002314: IPR 015807; KEGG: mth:MTH244 histidyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; PRIAM: Histidine--tRNA ligase; SPTR: O26346 Histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: ATP phosphoribosyltransferase, regulatory subunit; histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.
       0.876
Mfer_1192
Xylose isomerase domain protein TIM barrel; COGs: COG1082 Sugar phosphate isomerase/epimerase; InterPro IPR013022: IPR012307: IPR001719; KEGG: mst:Msp_0651 sugar phosphate isomerase/epimerase or endonuclease; PFAM: Xylose isomerase domain protein TIM barrel; SMART: AP endonuclease family 2; SPTR: Q2NGK4 Predicted sugar phosphate isomerase/epimerase or endonuclease; PFAM: Xylose isomerase-like TIM barrel.
       0.872
Mfer_1188
Protein of unknown function UPF0278; RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. Belongs to the HARP family.
 
     0.832
Mfer_1193
Reduced coenzyme F420:NADP oxidoreductase; COGs: COG2085 dinucleotide-binding protein; InterPro IPR016040: IPR004455: IPR010185; KEGG: mth:MTH248 hypothetical protein; PFAM: NADP oxidoreductase coenzyme F420-dependent; SPTR: O59661 F420-dependent NADP reductase; TIGRFAM: NADPH-dependent F420 reductase; PFAM: NADP oxidoreductase coenzyme F420-dependent; TIGRFAM: NADPH-dependent F420 reductase.
 
     0.791
Mfer_1194
COGs: COG0794 sugar phosphate isomerase involved in capsule formation; InterPro IPR001347: IPR017552; KEGG: mth:MTH249 hypothetical protein; PFAM: sugar isomerase (SIS); SPTR: O26351 Uncharacterized protein MTH_249; TIGRFAM: 6-phospho 3-hexuloisomerase; PFAM: SIS domain; TIGRFAM: 6-phospho 3-hexuloisomerase.
       0.760
trpS
tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp).
 
     0.739
Mfer_1195
COGs: COG1676 tRNA splicing endonuclease; InterPro IPR016442: IPR006677: IPR006678: IPR011856: IPR 006676; KEGG: mth:MTH250 tRNA-splicing endonuclease subunit alpha; PFAM: tRNA intron endonuclease, catalytic domain protein; tRNA intron endonuclease domain protein; PRIAM: tRNA-intron endonuclease; SPTR: O07165 tRNA-splicing endonuclease; TIGRFAM: tRNA intron endonuclease; PFAM: tRNA intron endonuclease, catalytic C-terminal domain; tRNA intron endonuclease, N-terminal domain; TIGRFAM: tRNA intron endonuclease.
 
     0.727
Mfer_1199
COGs: COG2036 Histones H3 and H4; InterPro IPR009072: IPR003958; KEGG: mth:MTH1696 histone HMtA2; PFAM: Transcription factor CBF/NF-Y/histone domain protein; SPTR: P19267 DNA-binding protein HMf-2; PFAM: Histone-like transcription factor (CBF/NF-Y) and archaeal histone.
 
     0.715
Mfer_1198
L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
       0.646
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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