STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_1278Metallophosphoesterase; COGs: COG1409 phosphohydrolase; InterPro IPR004843; KEGG: msi:Msm_0383 phosphohydrolase calcineurin-like superfamily; PFAM: metallophosphoesterase; SPTR: A5UK60 Predicted phosphohydrolase, calcineurin-like superfamily; PFAM: Calcineurin-like phosphoesterase. (247 aa)    
Predicted Functional Partners:
tgtA
Archaeosine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family.
  
    0.891
nac
Nascent polypeptide associated complex NAC; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family.
       0.866
Mfer_1276
KEGG: mth:MTH180 hypothetical protein; SPTR: O26282 Putative uncharacterized protein.
       0.865
Mfer_1277
KEGG: mth:MTH179 hypothetical protein; SPTR: O26281 Putative uncharacterized protein; PFAM: Zc3h12a-like Ribonuclease domain.
       0.865
Mfer_1281
Protein of unknown function DUF752; COGs: COG4121 conserved hypothetical protein; InterPro IPR008471; KEGG: mth:MTH175 hypothetical protein; PFAM: protein of unknown function DUF752; SPTR: O26277 Conserved protein; PFAM: Protein of unknown function (DUF752).
       0.778
Mfer_1282
Radical SAM domain protein; COGs: COG2896 Molybdenum cofactor biosynthesis protein; InterPro IPR006638: IPR007197; KEGG: mja:MJ1632 coenzyme PQQ synthesis protein (PqqE); PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: Q59026 Uncharacterized protein MJ1632; PFAM: Radical SAM superfamily.
       0.519
Mfer_0361
Nucleotidyl transferase; COGs: COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon); InterPro IPR011051: IPR005835: IPR013096; KEGG: mth:MTH1523 glucose-1-phosphate adenylyltransferase related protein; PFAM: Nucleotidyl transferase; Cupin 2 conserved barrel domain protein; SPTR: O27567 Glucose-1-phosphate adenylyltransferase related protein; PFAM: Nucleotidyl transferase; Mannose-6-phosphate isomerase.
     
 0.441
pgk2
COGs: COG2074 2-phosphoglycerate kinase; InterPro IPR005144; KEGG: mth:MTH1883 2-phosphoglycerate kinase; PFAM: ATP-cone domain protein; SPTR: Q49156 2-phosphoglycerate kinase; PFAM: ATP cone domain.
 
   
 0.438
leuS
COGs: COG0495 Leucyl-tRNA synthetase; InterPro IPR001412: IPR004493: IPR014729: IPR009008: IPR 009080: IPR015413: IPR002300: IPR013155; KEGG: mth:MTH1508 leucyl-tRNA synthetase; PFAM: tRNA synthetase valyl/leucyl anticodon-binding; aminoacyl-tRNA synthetase class Ia; tRNA synthetase class I (M); SPTR: O27552 Leucyl-tRNA synthetase; TIGRFAM: leucyl-tRNA synthetase; PFAM: tRNA synthetases class I (I, L, M and V); Anticodon-binding domain; TIGRFAM: leucyl-tRNA synthetase, archaeal and cytosolic family.
 
 
   0.408
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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