node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
TON_0028 | psmA | TON_0028 | TON_0027 | Predicted exosome subunit, UPF0023 family. | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.892 |
TON_0028 | rpl15e | TON_0028 | TON_0144 | Predicted exosome subunit, UPF0023 family. | LSU ribosomal protein L15E; Belongs to the eukaryotic ribosomal protein eL15 family. | 0.776 |
TON_0028 | rpl4 | TON_0028 | TON_0067 | Predicted exosome subunit, UPF0023 family. | LSU ribosomal protein L4P; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. | 0.826 |
TON_0028 | rrp4 | TON_0028 | TON_0029 | Predicted exosome subunit, UPF0023 family. | RNA-binding protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. | 0.869 |
TON_0028 | rrp41 | TON_0028 | TON_0030 | Predicted exosome subunit, UPF0023 family. | 3'-5' exoribonuclease; Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails. | 0.893 |
TON_0028 | rrp42 | TON_0028 | TON_0031 | Predicted exosome subunit, UPF0023 family. | 3'-5' exoribonuclease; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. | 0.865 |
glpK | pan | TON_0202 | TON_1385 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | 0.999 |
glpK | psmA | TON_0202 | TON_0027 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.758 |
glpK | psmB1 | TON_0202 | TON_0164 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | Proteasome, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.758 |
glpK | psmB2 | TON_0202 | TON_1426 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | Proteasome, beta subunit 2; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.758 |
pan | glpK | TON_1385 | TON_0202 | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | 0.999 |
pan | psmA | TON_1385 | TON_0027 | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.903 |
pan | psmB1 | TON_1385 | TON_0164 | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | Proteasome, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.788 |
pan | psmB2 | TON_1385 | TON_1426 | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | Proteasome, beta subunit 2; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.788 |
psmA | TON_0028 | TON_0027 | TON_0028 | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | Predicted exosome subunit, UPF0023 family. | 0.892 |
psmA | glpK | TON_0027 | TON_0202 | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. | 0.758 |
psmA | pan | TON_0027 | TON_1385 | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | 0.903 |
psmA | psmB1 | TON_0027 | TON_0164 | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | Proteasome, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.801 |
psmA | psmB2 | TON_0027 | TON_1426 | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | Proteasome, beta subunit 2; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.807 |
psmA | rpl15e | TON_0027 | TON_0144 | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | LSU ribosomal protein L15E; Belongs to the eukaryotic ribosomal protein eL15 family. | 0.781 |