STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gcvPBGlycine cleavage system protein P, subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (502 aa)    
Predicted Functional Partners:
gcvPA
Glycine cleavage system protein P, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
 
0.999
gcvH
Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 0.999
gcvT
Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine.
 0.999
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.990
TON_1415
2-amino-3-oxobutyrate coenzyme A ligase.
  
 
 0.929
TON_1268
Sarcosine oxidase, beta subunit (soxB).
  
 
 0.917
TON_1281
Sarcosine oxidase, beta subunit.
  
 
 0.917
TON_1265
Proline dehydrogenase, alpha subunit.
     
 0.911
TON_1282
Sarcosine oxidase, alpha subunit.
     
 0.911
TON_0157
Glutamate dehydrogenase (GDH); Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.860
Your Current Organism:
Thermococcus onnurineus
NCBI taxonomy Id: 523850
Other names: T. onnurineus NA1, Thermococcus onnurineus NA1, Thermococcus onnurineus str. NA1, Thermococcus onnurineus strain NA1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.