Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TON_0891N2, N2-dimethylguanosine tRNA methyltransferase. (331 aa)    
Predicted Functional Partners:
TON_1906
N5-glutamine methyltransferase; HemK family.
    
 
 0.597
TON_1943
Hypothetical nucleic acid-binding protein; Containing PIN domain.
  
    0.595
queE
Organic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
     
 0.587
TON_0453
Component of the U3 small nucleolar ribonucleoprotein; Probably involved in the biogenesis of the ribosome.
  
    0.582
TON_0356
Predicted GTPase; Containing NOG1 domain.
 
    0.577
TON_1052
Hypothetical nucleic acid-binding protein; Containing PIN domain and zinc-ribbon module.
  
    0.566
rtcA
RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
   
    0.561
TON_0306
Nonsense-mediated mRNA decay protein; NMD3-like protein.
  
    0.551
TON_1006
ThiI-related protein.
  
   
 0.535
tmcA
Hypothetical ATPase; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
   
  
 0.525
Your Current Organism:
Thermococcus onnurineus
NCBI taxonomy Id: 523850
Other names: T. onnurineus NA1, Thermococcus onnurineus NA1, Thermococcus onnurineus str. NA1, Thermococcus onnurineus strain NA1
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