STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadKATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (278 aa)    
Predicted Functional Partners:
nadE
NH3-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
 
  
 0.965
cobB
NAD-dependent protein deacetylase; Sir2p-like protein; Belongs to the sirtuin family. Class III subfamily.
  
 
 0.932
TON_1164
Nicotinamide mononucleotide adenylyltransferase.
    
 0.922
TON_1045
Archaeal inositol-1-monophosphatase/fructose-1, 6-bisphosphatase.
 
  
 0.916
TON_1630
tRNA/rRNA cytosine-C5-methylase; NOL1/NOP2/Sun family, containing RNA-binding PUA domain; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
    0.912
TON_1631
Hypothetical membrane protein, conserved; UPF0104 family.
 
     0.824
TON_1629
Conserved hypothetical protein.
       0.789
TON_1362
Nicotinate-nucleotide pyrophosphorylase.
 
   
 0.682
TON_1628
Hypothetical protein, conserved; Containing DUF1511 family.
       0.674
TON_1626
Hypothetical membrane protein.
       0.569
Your Current Organism:
Thermococcus onnurineus
NCBI taxonomy Id: 523850
Other names: T. onnurineus NA1, Thermococcus onnurineus NA1, Thermococcus onnurineus str. NA1, Thermococcus onnurineus strain NA1
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.