Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
TON_1968Nicotinamidase-like amidase. (179 aa)    
Predicted Functional Partners:
TON_1362
Nicotinate-nucleotide pyrophosphorylase.
 
 0.983
cobB
NAD-dependent protein deacetylase; Sir2p-like protein; Belongs to the sirtuin family. Class III subfamily.
   
 0.923
TON_0013
Hypothetical protein, conserved.
       0.813
TON_0012
Predicted thioesterase.
     
 0.812
TON_0399
3-hydroxy-3-methylglutaryl-CoA reductase; Belongs to the HMG-CoA reductase family.
    
 0.749
hisI
Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family.
  
    0.671
TON_1466
Hypothetical tRNA/rRNA methyltransferase; SpoU family.
 
      0.670
TON_0015
Binding-protein-dependent transport systems inner membrane component.
       0.601
pstB
Molybdenum-pterin binding domain protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
       0.601
TON_0010
Permease; Major facilitator family related.
  
    0.594
Your Current Organism:
Thermococcus onnurineus
NCBI taxonomy Id: 523850
Other names: T. onnurineus NA1, Thermococcus onnurineus NA1, Thermococcus onnurineus str. NA1, Thermococcus onnurineus strain NA1
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