node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEH64335.1 | EEH64337.1 | HMPREF0044_0072 | HMPREF0044_0074 | Glutaredoxin; COG: COG0695; Pfam: PF00462; InterPro: IPR012335. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.999 |
EEH64335.1 | EEH64431.1 | HMPREF0044_0072 | HMPREF0044_0168 | Glutaredoxin; COG: COG0695; Pfam: PF00462; InterPro: IPR012335. | Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | 0.973 |
EEH64335.1 | adk | HMPREF0044_0072 | HMPREF0044_0420 | Glutaredoxin; COG: COG0695; Pfam: PF00462; InterPro: IPR012335. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.454 |
EEH64335.1 | ndk | HMPREF0044_0072 | HMPREF0044_1160 | Glutaredoxin; COG: COG0695; Pfam: PF00462; InterPro: IPR012335. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.442 |
EEH64335.1 | nrdI | HMPREF0044_0072 | HMPREF0044_0073 | Glutaredoxin; COG: COG0695; Pfam: PF00462; InterPro: IPR012335. | nrdI protein; Probably involved in ribonucleotide reductase function. | 0.990 |
EEH64335.1 | pyk | HMPREF0044_0072 | HMPREF0044_1096 | Glutaredoxin; COG: COG0695; Pfam: PF00462; InterPro: IPR012335. | Pyruvate kinase; COG: COG0469; Pfam: PF00224,PF02887; InterPro: IPR001697; Belongs to the pyruvate kinase family. | 0.449 |
EEH64335.1 | tmk | HMPREF0044_0072 | HMPREF0044_1523 | Glutaredoxin; COG: COG0695; Pfam: PF00462; InterPro: IPR012335. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.461 |
EEH64337.1 | EEH64335.1 | HMPREF0044_0074 | HMPREF0044_0072 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Glutaredoxin; COG: COG0695; Pfam: PF00462; InterPro: IPR012335. | 0.999 |
EEH64337.1 | EEH64431.1 | HMPREF0044_0074 | HMPREF0044_0168 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | 0.999 |
EEH64337.1 | adk | HMPREF0044_0074 | HMPREF0044_0420 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.972 |
EEH64337.1 | der | HMPREF0044_0074 | HMPREF0044_1270 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Ribosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the cytidylate kinase family. Type 1 subfamily. | 0.864 |
EEH64337.1 | gmk | HMPREF0044_0074 | HMPREF0044_1299 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.967 |
EEH64337.1 | ndk | HMPREF0044_0074 | HMPREF0044_1160 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.968 |
EEH64337.1 | nrdI | HMPREF0044_0074 | HMPREF0044_0073 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | nrdI protein; Probably involved in ribonucleotide reductase function. | 0.998 |
EEH64337.1 | polA | HMPREF0044_0074 | HMPREF0044_1109 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.838 |
EEH64337.1 | pyk | HMPREF0044_0074 | HMPREF0044_1096 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Pyruvate kinase; COG: COG0469; Pfam: PF00224,PF02887; InterPro: IPR001697; Belongs to the pyruvate kinase family. | 0.932 |
EEH64337.1 | tmk | HMPREF0044_0074 | HMPREF0044_1523 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.953 |
EEH64431.1 | EEH64335.1 | HMPREF0044_0168 | HMPREF0044_0072 | Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | Glutaredoxin; COG: COG0695; Pfam: PF00462; InterPro: IPR012335. | 0.973 |
EEH64431.1 | EEH64337.1 | HMPREF0044_0168 | HMPREF0044_0074 | Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.999 |
EEH64431.1 | adk | HMPREF0044_0168 | HMPREF0044_0420 | Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.944 |