node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEH63734.1 | EEH64473.1 | HMPREF0044_0753 | HMPREF0044_0210 | Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF02872; InterPro: IPR006179. | 0.960 |
EEH63734.1 | add | HMPREF0044_0753 | HMPREF0044_0382 | Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Adenosine deaminase; COG: COG1816; Pfam: PF00962; InterPro: IPR001365. | 0.973 |
EEH63734.1 | apt | HMPREF0044_0753 | HMPREF0044_1338 | Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.980 |
EEH63734.1 | deoD | HMPREF0044_0753 | HMPREF0044_1404 | Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Purine nucleoside phosphorylase; COG: COG0813; Pfam: PF01048; InterPro: IPR004402. | 0.944 |
EEH63734.1 | guaA | HMPREF0044_0753 | HMPREF0044_0719 | Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.748 |
EEH63734.1 | guaB | HMPREF0044_0753 | HMPREF0044_0693 | Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.659 |
EEH63734.1 | hpt | HMPREF0044_0753 | HMPREF0044_0347 | Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Hypoxanthine phosphoribosyltransferase; COG: COG0634; Pfam: PF00156; InterPro: IPR005904; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.976 |
EEH64473.1 | EEH63734.1 | HMPREF0044_0210 | HMPREF0044_0753 | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF02872; InterPro: IPR006179. | Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.960 |
EEH64473.1 | add | HMPREF0044_0210 | HMPREF0044_0382 | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF02872; InterPro: IPR006179. | Adenosine deaminase; COG: COG1816; Pfam: PF00962; InterPro: IPR001365. | 0.961 |
EEH64473.1 | apt | HMPREF0044_0210 | HMPREF0044_1338 | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF02872; InterPro: IPR006179. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.947 |
EEH64473.1 | deoD | HMPREF0044_0210 | HMPREF0044_1404 | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF02872; InterPro: IPR006179. | Purine nucleoside phosphorylase; COG: COG0813; Pfam: PF01048; InterPro: IPR004402. | 0.934 |
EEH64473.1 | guaA | HMPREF0044_0210 | HMPREF0044_0719 | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF02872; InterPro: IPR006179. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.934 |
EEH64473.1 | guaB | HMPREF0044_0210 | HMPREF0044_0693 | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF02872; InterPro: IPR006179. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.964 |
EEH64473.1 | hpt | HMPREF0044_0210 | HMPREF0044_0347 | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF02872; InterPro: IPR006179. | Hypoxanthine phosphoribosyltransferase; COG: COG0634; Pfam: PF00156; InterPro: IPR005904; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.910 |
EEH64473.1 | purA | HMPREF0044_0210 | HMPREF0044_1486 | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF02872; InterPro: IPR006179. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.922 |
EEH64473.1 | purH | HMPREF0044_0210 | HMPREF0044_0589 | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF02872; InterPro: IPR006179. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG: COG0138; Pfam: PF02142,PF01808; InterPro: IPR002695. | 0.919 |
EEH64644.1 | add | HMPREF0044_0381 | HMPREF0044_0382 | Hydrolase, alpha/beta domain protein; Pfam: PF00561,PF07819; InterPro: IPR000073. | Adenosine deaminase; COG: COG1816; Pfam: PF00962; InterPro: IPR001365. | 0.779 |
add | EEH63734.1 | HMPREF0044_0382 | HMPREF0044_0753 | Adenosine deaminase; COG: COG1816; Pfam: PF00962; InterPro: IPR001365. | Purine nucleotide phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.973 |
add | EEH64473.1 | HMPREF0044_0382 | HMPREF0044_0210 | Adenosine deaminase; COG: COG1816; Pfam: PF00962; InterPro: IPR001365. | LPXTG-motif cell wall anchor domain protein; COG: COG0737; Pfam: PF02872; InterPro: IPR006179. | 0.961 |
add | EEH64644.1 | HMPREF0044_0382 | HMPREF0044_0381 | Adenosine deaminase; COG: COG1816; Pfam: PF00962; InterPro: IPR001365. | Hydrolase, alpha/beta domain protein; Pfam: PF00561,PF07819; InterPro: IPR000073. | 0.779 |