node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEH64212.1 | EEH64215.1 | HMPREF0044_0501 | HMPREF0044_0504 | Cell cycle protein, FtsW/RodA/SpoVE family; COG: COG0772; Pfam: PF01098; InterPro: IPR001182; Belongs to the SEDS family. | POTRA domain protein, FtsQ-type; Essential cell division protein. | 0.992 |
EEH64212.1 | ddl-2 | HMPREF0044_0501 | HMPREF0044_1152 | Cell cycle protein, FtsW/RodA/SpoVE family; COG: COG0772; Pfam: PF01098; InterPro: IPR001182; Belongs to the SEDS family. | D-ala D-ala ligase N-terminal domain protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | 0.748 |
EEH64212.1 | ftsZ | HMPREF0044_0501 | HMPREF0044_0505 | Cell cycle protein, FtsW/RodA/SpoVE family; COG: COG0772; Pfam: PF01098; InterPro: IPR001182; Belongs to the SEDS family. | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.971 |
EEH64212.1 | mraY | HMPREF0044_0501 | HMPREF0044_0499 | Cell cycle protein, FtsW/RodA/SpoVE family; COG: COG0772; Pfam: PF01098; InterPro: IPR001182; Belongs to the SEDS family. | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | 0.978 |
EEH64212.1 | murC | HMPREF0044_0501 | HMPREF0044_0503 | Cell cycle protein, FtsW/RodA/SpoVE family; COG: COG0772; Pfam: PF01098; InterPro: IPR001182; Belongs to the SEDS family. | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.986 |
EEH64212.1 | murD | HMPREF0044_0501 | HMPREF0044_0500 | Cell cycle protein, FtsW/RodA/SpoVE family; COG: COG0772; Pfam: PF01098; InterPro: IPR001182; Belongs to the SEDS family. | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.993 |
EEH64212.1 | murE | HMPREF0044_0501 | HMPREF0044_0974 | Cell cycle protein, FtsW/RodA/SpoVE family; COG: COG0772; Pfam: PF01098; InterPro: IPR001182; Belongs to the SEDS family. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; COG: COG0769; Pfam: PF01225,PF08245,PF02875; InterPro: IPR005761; Belongs to the MurCDEF family. MurE subfamily. | 0.861 |
EEH64212.1 | murF | HMPREF0044_0501 | HMPREF0044_0498 | Cell cycle protein, FtsW/RodA/SpoVE family; COG: COG0772; Pfam: PF01098; InterPro: IPR001182; Belongs to the SEDS family. | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.982 |
EEH64212.1 | murG | HMPREF0044_0501 | HMPREF0044_0502 | Cell cycle protein, FtsW/RodA/SpoVE family; COG: COG0772; Pfam: PF01098; InterPro: IPR001182; Belongs to the SEDS family. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.998 |
EEH64215.1 | EEH64212.1 | HMPREF0044_0504 | HMPREF0044_0501 | POTRA domain protein, FtsQ-type; Essential cell division protein. | Cell cycle protein, FtsW/RodA/SpoVE family; COG: COG0772; Pfam: PF01098; InterPro: IPR001182; Belongs to the SEDS family. | 0.992 |
EEH64215.1 | EEH64593.1 | HMPREF0044_0504 | HMPREF0044_0330 | POTRA domain protein, FtsQ-type; Essential cell division protein. | Putative phage prohead protease, HK97 family; COG: COG0769; Pfam: PF08245,PF08353; InterPro: IPR013221. | 0.427 |
EEH64215.1 | ddl-2 | HMPREF0044_0504 | HMPREF0044_1152 | POTRA domain protein, FtsQ-type; Essential cell division protein. | D-ala D-ala ligase N-terminal domain protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | 0.645 |
EEH64215.1 | ftsZ | HMPREF0044_0504 | HMPREF0044_0505 | POTRA domain protein, FtsQ-type; Essential cell division protein. | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.964 |
EEH64215.1 | mraY | HMPREF0044_0504 | HMPREF0044_0499 | POTRA domain protein, FtsQ-type; Essential cell division protein. | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | 0.746 |
EEH64215.1 | murC | HMPREF0044_0504 | HMPREF0044_0503 | POTRA domain protein, FtsQ-type; Essential cell division protein. | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.966 |
EEH64215.1 | murD | HMPREF0044_0504 | HMPREF0044_0500 | POTRA domain protein, FtsQ-type; Essential cell division protein. | UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.953 |
EEH64215.1 | murE | HMPREF0044_0504 | HMPREF0044_0974 | POTRA domain protein, FtsQ-type; Essential cell division protein. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; COG: COG0769; Pfam: PF01225,PF08245,PF02875; InterPro: IPR005761; Belongs to the MurCDEF family. MurE subfamily. | 0.738 |
EEH64215.1 | murF | HMPREF0044_0504 | HMPREF0044_0498 | POTRA domain protein, FtsQ-type; Essential cell division protein. | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.921 |
EEH64215.1 | murG | HMPREF0044_0504 | HMPREF0044_0502 | POTRA domain protein, FtsQ-type; Essential cell division protein. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.994 |
EEH64593.1 | EEH64215.1 | HMPREF0044_0330 | HMPREF0044_0504 | Putative phage prohead protease, HK97 family; COG: COG0769; Pfam: PF08245,PF08353; InterPro: IPR013221. | POTRA domain protein, FtsQ-type; Essential cell division protein. | 0.427 |