STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glnE[glutamate--ammonia-ligase] adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...] (987 aa)    
Predicted Functional Partners:
EEH64029.1
Glutamine synthetase, beta-grasp domain protein; COG: COG0174; Pfam: PF03951,PF00120; InterPro: IPR014746; Belongs to the glutamine synthetase family.
  
  
 0.959
glnA
Glutamine synthetase, type I; COG: COG0174; Pfam: PF03951,PF00120; InterPro: IPR004809.
 
  
 0.952
crgA
Hypothetical protein; Involved in cell division; Belongs to the CrgA family.
      
 0.681
EEH64031.1
Phosphoglycerate mutase family protein; Pfam: PF00300; InterPro: IPR013078.
       0.671
nadE
Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
     
 0.658
EEH63430.1
3'-5' exonuclease; COG: COG0349; Pfam: PF01612,PF00570; InterPro: IPR002562.
  
     0.653
EEH63935.1
Putative DNA polymerase III, delta subunit; COG: COG1466; Pfam: PF06144.
  
     0.619
EEH63445.1
Hypothetical protein.
  
     0.618
rbpA
Hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
  
     0.571
EEH64028.1
SPFH/Band 7/PHB domain protein; COG: COG0330; Pfam: PF01145; InterPro: IPR001107.
       0.543
Your Current Organism:
Gleimia coleocanis
NCBI taxonomy Id: 525245
Other names: Actinomyces coleocanis DSM 15436, Actinomyces coleocanis str. DSM 15436, Actinomyces coleocanis strain DSM 15436, G. coleocanis DSM 15436, Gleimia coleocanis DSM 15436
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