STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ileSisoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1079 aa)    
Predicted Functional Partners:
proS
proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacy [...]
   
 0.998
leuS
leucine--tRNA ligase; COG: COG0495; Pfam: PF09334,PF00133,PF08264; InterPro: IPR002302; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 0.998
argS
arginine--tRNA ligase; COG: COG0018; Pfam: PF03485,PF00750,PF05746; InterPro: IPR001278.
  
 0.995
pheT
phenylalanine--tRNA ligase, beta subunit; COG: COG0072; Pfam: PF01588,PF03483,PF03484,PF03147; InterPro: IPR004532; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
  
 
 0.994
metG
methionine--tRNA ligase; COG: COG0143; Pfam: PF09334; InterPro: IPR002304; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 0.986
gltX
glutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
 
 0.981
EEH63274.1
Putative glutamyl-queuosine tRNA(Asp) synthetase; COG: COG0008; Pfam: PF00749; InterPro: IPR000924; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 0.951
lysS-2
lysine--tRNA ligase; COG: COG1190; Pfam: PF01336,PF00152; InterPro: IPR002313; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
 0.943
lysS
lysine--tRNA ligase; COG: COG1190; Pfam: PF04329,PF04330,PF04331,PF01336,PF00152; InterPro: IPR002313; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
 0.938
valS
Anticodon-binding domain protein; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner.
 
0.911
Your Current Organism:
Gleimia coleocanis
NCBI taxonomy Id: 525245
Other names: Actinomyces coleocanis DSM 15436, Actinomyces coleocanis str. DSM 15436, Actinomyces coleocanis strain DSM 15436, G. coleocanis DSM 15436, Gleimia coleocanis DSM 15436
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.