Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
dprADNA protecting protein DprA; COG: COG0758; Pfam: PF02481; InterPro: IPR003488. (363 aa)    
Predicted Functional Partners:
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 0.929
EEI85415.1
Putative TIGR00252 family protein; COG: COG0792; Pfam: PF02021; InterPro: IPR003509; Belongs to the UPF0102 family.
 
  
 0.928
EEI85262.1
comF family protein; COG: COG1040; Pfam: PF00156.
 
 
 0.911
EEI85316.1
DNA internalization competence protein ComEC/Rec2-like protein; COG: COG2333; Pfam: PF03772,PF00753; InterPro: IPR004797.
 
  
 0.882
EEI87375.1
Bacterial peptidase A24, N-terminal domain protein; COG: COG1989; Pfam: PF06750,PF01478; InterPro: IPR010627.
 
  
 0.879
EEI85625.1
Mg chelatase-like protein; COG: COG0606; Pfam: PF01078; InterPro: IPR004482.
 
 
 0.863
rnhB
Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
  
    0.825
ylqF
Ribosome biogenesis GTP-binding protein YlqF; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
  
    0.821
EEI85626.1
Type II/IV secretion system protein; COG: COG2804; Pfam: PF00437; InterPro: IPR001482.
  
  
 0.704
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
   
 
 0.679
Your Current Organism:
Anaerococcus lactolyticus
NCBI taxonomy Id: 525254
Other names: A. lactolyticus ATCC 51172, Anaerococcus lactolyticus ATCC 51172, Anaerococcus lactolyticus str. ATCC 51172, Anaerococcus lactolyticus strain ATCC 51172
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