node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | HMPREF0204_13915 | HMPREF0204_13917 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; COG: COG0106; Pfam: PF00977; InterPro: IPR013785; overlaps another CDS with the same product name. | Histidinol-phosphatase; COG: COG0131; Pfam: PF08645,PF00475; InterPro: IPR000807; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.999 |
hisA | hisC | HMPREF0204_13915 | HMPREF0204_13918 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; COG: COG0106; Pfam: PF00977; InterPro: IPR013785; overlaps another CDS with the same product name. | Histidinol-phosphate transaminase; COG: COG0079; Pfam: PF00155; InterPro: IPR005861. | 0.992 |
hisA | hisD | HMPREF0204_13915 | HMPREF0204_13919 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; COG: COG0106; Pfam: PF00977; InterPro: IPR013785; overlaps another CDS with the same product name. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |
hisA | hisE | HMPREF0204_13915 | HMPREF0204_13913 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; COG: COG0106; Pfam: PF00977; InterPro: IPR013785; overlaps another CDS with the same product name. | phosphoribosyl-ATP diphosphatase; COG: COG0139; Pfam: PF01502,PF01503; InterPro: IPR008179; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisA | hisF | HMPREF0204_13915 | HMPREF0204_13914 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; COG: COG0106; Pfam: PF00977; InterPro: IPR013785; overlaps another CDS with the same product name. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisF_2 | HMPREF0204_13915 | HMPREF0204_12138 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; COG: COG0106; Pfam: PF00977; InterPro: IPR013785; overlaps another CDS with the same product name. | Putative imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.982 |
hisA | hisG | HMPREF0204_13915 | HMPREF0204_13920 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; COG: COG0106; Pfam: PF00977; InterPro: IPR013785; overlaps another CDS with the same product name. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.995 |
hisA | hisH-2 | HMPREF0204_13915 | HMPREF0204_13916 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; COG: COG0106; Pfam: PF00977; InterPro: IPR013785; overlaps another CDS with the same product name. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisA | HMPREF0204_13917 | HMPREF0204_13915 | Histidinol-phosphatase; COG: COG0131; Pfam: PF08645,PF00475; InterPro: IPR000807; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; COG: COG0106; Pfam: PF00977; InterPro: IPR013785; overlaps another CDS with the same product name. | 0.999 |
hisB | hisC | HMPREF0204_13917 | HMPREF0204_13918 | Histidinol-phosphatase; COG: COG0131; Pfam: PF08645,PF00475; InterPro: IPR000807; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Histidinol-phosphate transaminase; COG: COG0079; Pfam: PF00155; InterPro: IPR005861. | 0.999 |
hisB | hisD | HMPREF0204_13917 | HMPREF0204_13919 | Histidinol-phosphatase; COG: COG0131; Pfam: PF08645,PF00475; InterPro: IPR000807; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisE | HMPREF0204_13917 | HMPREF0204_13913 | Histidinol-phosphatase; COG: COG0131; Pfam: PF08645,PF00475; InterPro: IPR000807; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | phosphoribosyl-ATP diphosphatase; COG: COG0139; Pfam: PF01502,PF01503; InterPro: IPR008179; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisB | hisF | HMPREF0204_13917 | HMPREF0204_13914 | Histidinol-phosphatase; COG: COG0131; Pfam: PF08645,PF00475; InterPro: IPR000807; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisF_2 | HMPREF0204_13917 | HMPREF0204_12138 | Histidinol-phosphatase; COG: COG0131; Pfam: PF08645,PF00475; InterPro: IPR000807; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Putative imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | HMPREF0204_13917 | HMPREF0204_13920 | Histidinol-phosphatase; COG: COG0131; Pfam: PF08645,PF00475; InterPro: IPR000807; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.997 |
hisB | hisH-2 | HMPREF0204_13917 | HMPREF0204_13916 | Histidinol-phosphatase; COG: COG0131; Pfam: PF08645,PF00475; InterPro: IPR000807; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisS | HMPREF0204_13917 | HMPREF0204_13468 | Histidinol-phosphatase; COG: COG0131; Pfam: PF08645,PF00475; InterPro: IPR000807; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | histidine--tRNA ligase; COG: COG0124; Pfam: PF00587,PF03129; InterPro: IPR015807. | 0.515 |
hisB | prs | HMPREF0204_13917 | HMPREF0204_10447 | Histidinol-phosphatase; COG: COG0131; Pfam: PF08645,PF00475; InterPro: IPR000807; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Ribose-phosphate diphosphokinase; COG: COG0462; Pfam: PF00156; InterPro: IPR005946. | 0.411 |
hisC | hisA | HMPREF0204_13918 | HMPREF0204_13915 | Histidinol-phosphate transaminase; COG: COG0079; Pfam: PF00155; InterPro: IPR005861. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; COG: COG0106; Pfam: PF00977; InterPro: IPR013785; overlaps another CDS with the same product name. | 0.992 |
hisC | hisB | HMPREF0204_13918 | HMPREF0204_13917 | Histidinol-phosphate transaminase; COG: COG0079; Pfam: PF00155; InterPro: IPR005861. | Histidinol-phosphatase; COG: COG0131; Pfam: PF08645,PF00475; InterPro: IPR000807; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.999 |