node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFH93358.1 | yeaZ | HMPREF0391_11016 | HMPREF0391_10369 | Putative DNA metabolism protein. | Universal bacterial protein YeaZ; COG: COG1214; Pfam: PF00814; InterPro: IPR000905. | 0.636 |
EFH93407.1 | guaA | HMPREF0391_11065 | HMPREF0391_10793 | biotin--[acetyl-CoA-carboxylase] ligase; COG: COG0340; Pfam: PF03099; InterPro: IPR004408. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.484 |
EFH93407.1 | tadA | HMPREF0391_11065 | HMPREF0391_10296 | biotin--[acetyl-CoA-carboxylase] ligase; COG: COG0340; Pfam: PF03099; InterPro: IPR004408. | Cytidine and deoxycytidylate deaminase zinc-binding region; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.634 |
EFH93407.1 | yeaZ | HMPREF0391_11065 | HMPREF0391_10369 | biotin--[acetyl-CoA-carboxylase] ligase; COG: COG0340; Pfam: PF03099; InterPro: IPR004408. | Universal bacterial protein YeaZ; COG: COG1214; Pfam: PF00814; InterPro: IPR000905. | 0.667 |
EFH94002.1 | EFH94003.1 | HMPREF0391_10370 | HMPREF0391_10371 | Hydrolase, P-loop family; COG: COG0802; Pfam: PF02367; InterPro: IPR003442. | Hypothetical protein; Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins; Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family. | 0.570 |
EFH94002.1 | rimI | HMPREF0391_10370 | HMPREF0391_10368 | Hydrolase, P-loop family; COG: COG0802; Pfam: PF02367; InterPro: IPR003442. | Ribosomal-protein-alanine acetyltransferase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.996 |
EFH94002.1 | tilS | HMPREF0391_10370 | HMPREF0391_11729 | Hydrolase, P-loop family; COG: COG0802; Pfam: PF02367; InterPro: IPR003442. | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.406 |
EFH94002.1 | yeaZ | HMPREF0391_10370 | HMPREF0391_10369 | Hydrolase, P-loop family; COG: COG0802; Pfam: PF02367; InterPro: IPR003442. | Universal bacterial protein YeaZ; COG: COG1214; Pfam: PF00814; InterPro: IPR000905. | 0.998 |
EFH94003.1 | EFH94002.1 | HMPREF0391_10371 | HMPREF0391_10370 | Hypothetical protein; Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins; Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family. | Hydrolase, P-loop family; COG: COG0802; Pfam: PF02367; InterPro: IPR003442. | 0.570 |
EFH94003.1 | rimI | HMPREF0391_10371 | HMPREF0391_10368 | Hypothetical protein; Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins; Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family. | Ribosomal-protein-alanine acetyltransferase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.621 |
EFH94003.1 | yeaZ | HMPREF0391_10371 | HMPREF0391_10369 | Hypothetical protein; Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins; Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family. | Universal bacterial protein YeaZ; COG: COG1214; Pfam: PF00814; InterPro: IPR000905. | 0.563 |
guaA | EFH93407.1 | HMPREF0391_10793 | HMPREF0391_11065 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | biotin--[acetyl-CoA-carboxylase] ligase; COG: COG0340; Pfam: PF03099; InterPro: IPR004408. | 0.484 |
guaA | rimI | HMPREF0391_10793 | HMPREF0391_10368 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Ribosomal-protein-alanine acetyltransferase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.675 |
guaA | tadA | HMPREF0391_10793 | HMPREF0391_10296 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Cytidine and deoxycytidylate deaminase zinc-binding region; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.557 |
guaA | tilS | HMPREF0391_10793 | HMPREF0391_11729 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.932 |
guaA | truA | HMPREF0391_10793 | HMPREF0391_10261 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. | 0.418 |
guaA | yeaZ | HMPREF0391_10793 | HMPREF0391_10369 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Universal bacterial protein YeaZ; COG: COG1214; Pfam: PF00814; InterPro: IPR000905. | 0.458 |
recR | yeaZ | HMPREF0391_10569 | HMPREF0391_10369 | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | Universal bacterial protein YeaZ; COG: COG1214; Pfam: PF00814; InterPro: IPR000905. | 0.424 |
rimI | EFH94002.1 | HMPREF0391_10368 | HMPREF0391_10370 | Ribosomal-protein-alanine acetyltransferase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | Hydrolase, P-loop family; COG: COG0802; Pfam: PF02367; InterPro: IPR003442. | 0.996 |
rimI | EFH94003.1 | HMPREF0391_10368 | HMPREF0391_10371 | Ribosomal-protein-alanine acetyltransferase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | Hypothetical protein; Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins; Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family. | 0.621 |