node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFH92783.1 | EFH93667.1 | HMPREF0391_11755 | HMPREF0391_10035 | Putative lipid kinase; COG: COG1597; Pfam: PF00781; InterPro: IPR005218. | Lipid kinase, YegS/Rv2252/BmrU family; Pfam: PF00781; InterPro: IPR001206. | 0.906 |
EFH92783.1 | groL | HMPREF0391_11755 | HMPREF0391_11633 | Putative lipid kinase; COG: COG1597; Pfam: PF00781; InterPro: IPR005218. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.838 |
EFH93240.1 | EFH93667.1 | HMPREF0391_10898 | HMPREF0391_10035 | Lipid kinase, YegS/Rv2252/BmrU family; COG: COG1597; Pfam: PF00781; InterPro: IPR005218. | Lipid kinase, YegS/Rv2252/BmrU family; Pfam: PF00781; InterPro: IPR001206. | 0.723 |
EFH93240.1 | groL | HMPREF0391_10898 | HMPREF0391_11633 | Lipid kinase, YegS/Rv2252/BmrU family; COG: COG1597; Pfam: PF00781; InterPro: IPR005218. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.838 |
EFH93313.1 | dnaK | HMPREF0391_10971 | HMPREF0391_11522 | DnaJ domain protein; COG: COG2214; Pfam: PF00226,PF01556; InterPro: IPR015609. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.999 |
EFH93313.1 | groL | HMPREF0391_10971 | HMPREF0391_11633 | DnaJ domain protein; COG: COG2214; Pfam: PF00226,PF01556; InterPro: IPR015609. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.805 |
EFH93313.1 | groS | HMPREF0391_10971 | HMPREF0391_11634 | DnaJ domain protein; COG: COG2214; Pfam: PF00226,PF01556; InterPro: IPR015609. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.700 |
EFH93313.1 | grpE | HMPREF0391_10971 | HMPREF0391_11523 | DnaJ domain protein; COG: COG2214; Pfam: PF00226,PF01556; InterPro: IPR015609. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.931 |
EFH93313.1 | hrcA | HMPREF0391_10971 | HMPREF0391_11524 | DnaJ domain protein; COG: COG2214; Pfam: PF00226,PF01556; InterPro: IPR015609. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.741 |
EFH93313.1 | lon | HMPREF0391_10971 | HMPREF0391_10357 | DnaJ domain protein; COG: COG2214; Pfam: PF00226,PF01556; InterPro: IPR015609. | Endopeptidase La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.637 |
EFH93667.1 | EFH92783.1 | HMPREF0391_10035 | HMPREF0391_11755 | Lipid kinase, YegS/Rv2252/BmrU family; Pfam: PF00781; InterPro: IPR001206. | Putative lipid kinase; COG: COG1597; Pfam: PF00781; InterPro: IPR005218. | 0.906 |
EFH93667.1 | EFH93240.1 | HMPREF0391_10035 | HMPREF0391_10898 | Lipid kinase, YegS/Rv2252/BmrU family; Pfam: PF00781; InterPro: IPR001206. | Lipid kinase, YegS/Rv2252/BmrU family; COG: COG1597; Pfam: PF00781; InterPro: IPR005218. | 0.723 |
EFH93667.1 | groL | HMPREF0391_10035 | HMPREF0391_11633 | Lipid kinase, YegS/Rv2252/BmrU family; Pfam: PF00781; InterPro: IPR001206. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.838 |
dnaJ | dnaK | HMPREF0391_11521 | HMPREF0391_11522 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.999 |
dnaJ | groL | HMPREF0391_11521 | HMPREF0391_11633 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.821 |
dnaJ | groS | HMPREF0391_11521 | HMPREF0391_11634 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.659 |
dnaJ | grpE | HMPREF0391_11521 | HMPREF0391_11523 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.976 |
dnaJ | hrcA | HMPREF0391_11521 | HMPREF0391_11524 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.863 |
dnaJ | lon | HMPREF0391_11521 | HMPREF0391_10357 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Endopeptidase La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.637 |
dnaK | EFH93313.1 | HMPREF0391_11522 | HMPREF0391_10971 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | DnaJ domain protein; COG: COG2214; Pfam: PF00226,PF01556; InterPro: IPR015609. | 0.999 |