node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEW54318.1 | gmk2 | HMPREF0494_0501 | HMPREF0494_0659 | Phosphoribosyl transferase domain protein; COG: COG0503; Pfam: PF00156; InterPro: IPR000836. | Guanylate kinase; COG: COG0194; Pfam: PF00625; InterPro: IPR008145. | 0.953 |
EEW54318.1 | guaA-2 | HMPREF0494_0501 | HMPREF0494_0690 | Phosphoribosyl transferase domain protein; COG: COG0503; Pfam: PF00156; InterPro: IPR000836. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.986 |
EEW54318.1 | guaC | HMPREF0494_0501 | HMPREF0494_0351 | Phosphoribosyl transferase domain protein; COG: COG0503; Pfam: PF00156; InterPro: IPR000836. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.934 |
EEW54318.1 | hpt | HMPREF0494_0501 | HMPREF0494_0259 | Phosphoribosyl transferase domain protein; COG: COG0503; Pfam: PF00156; InterPro: IPR000836. | Hypoxanthine phosphoribosyltransferase; COG: COG0634; Pfam: PF00156; InterPro: IPR005904; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.938 |
EEW54318.1 | purA | HMPREF0494_0501 | HMPREF0494_0350 | Phosphoribosyl transferase domain protein; COG: COG0503; Pfam: PF00156; InterPro: IPR000836. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.641 |
EEW54318.1 | purB | HMPREF0494_0501 | HMPREF0494_0287 | Phosphoribosyl transferase domain protein; COG: COG0503; Pfam: PF00156; InterPro: IPR000836. | Adenylosuccinate lyase; COG: COG0015; Pfam: PF00206; InterPro: IPR004769; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.962 |
EEW54318.1 | purH | HMPREF0494_0501 | HMPREF0494_0277 | Phosphoribosyl transferase domain protein; COG: COG0503; Pfam: PF00156; InterPro: IPR000836. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG: COG0138; Pfam: PF02142,PF01808; InterPro: IPR002695. | 0.960 |
EEW54318.1 | xpt | HMPREF0494_0501 | HMPREF0494_0864 | Phosphoribosyl transferase domain protein; COG: COG0503; Pfam: PF00156; InterPro: IPR000836. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.928 |
apt | gmk2 | HMPREF0494_1398 | HMPREF0494_0659 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; COG: COG0194; Pfam: PF00625; InterPro: IPR008145. | 0.957 |
apt | guaA-2 | HMPREF0494_1398 | HMPREF0494_0690 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.992 |
apt | guaB | HMPREF0494_1398 | HMPREF0494_0318 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.463 |
apt | guaC | HMPREF0494_1398 | HMPREF0494_0351 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.959 |
apt | hpt | HMPREF0494_1398 | HMPREF0494_0259 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine phosphoribosyltransferase; COG: COG0634; Pfam: PF00156; InterPro: IPR005904; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.958 |
apt | purA | HMPREF0494_1398 | HMPREF0494_0350 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.812 |
apt | purB | HMPREF0494_1398 | HMPREF0494_0287 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate lyase; COG: COG0015; Pfam: PF00206; InterPro: IPR004769; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.974 |
apt | purH | HMPREF0494_1398 | HMPREF0494_0277 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG: COG0138; Pfam: PF02142,PF01808; InterPro: IPR002695. | 0.969 |
apt | xpt | HMPREF0494_1398 | HMPREF0494_0864 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.943 |
gmk2 | EEW54318.1 | HMPREF0494_0659 | HMPREF0494_0501 | Guanylate kinase; COG: COG0194; Pfam: PF00625; InterPro: IPR008145. | Phosphoribosyl transferase domain protein; COG: COG0503; Pfam: PF00156; InterPro: IPR000836. | 0.953 |
gmk2 | apt | HMPREF0494_0659 | HMPREF0494_1398 | Guanylate kinase; COG: COG0194; Pfam: PF00625; InterPro: IPR008145. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.957 |
gmk2 | guaA-2 | HMPREF0494_0659 | HMPREF0494_0690 | Guanylate kinase; COG: COG0194; Pfam: PF00625; InterPro: IPR008145. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.981 |