node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEW53280.1 | ribA | HMPREF0494_1563 | HMPREF0494_0462 | Cof-like hydrolase; COG: COG0561; Pfam: PF08282; InterPro: IPR000150. | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | 0.490 |
EEW53280.1 | ribB | HMPREF0494_1563 | HMPREF0494_0494 | Cof-like hydrolase; COG: COG0561; Pfam: PF08282; InterPro: IPR000150. | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. Belongs to the DHBP synthase family. | 0.479 |
EEW53280.1 | ribD | HMPREF0494_1563 | HMPREF0494_0460 | Cof-like hydrolase; COG: COG0561; Pfam: PF08282; InterPro: IPR000150. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.924 |
EEW53280.1 | ribE | HMPREF0494_1563 | HMPREF0494_0461 | Cof-like hydrolase; COG: COG0561; Pfam: PF08282; InterPro: IPR000150. | Riboflavin synthase, alpha subunit; COG: COG0307; Pfam: PF00677; InterPro: IPR001783. | 0.908 |
EEW53280.1 | ribF | HMPREF0494_1563 | HMPREF0494_1427 | Cof-like hydrolase; COG: COG0561; Pfam: PF08282; InterPro: IPR000150. | Riboflavin biosynthesis protein RibF; COG: COG0196; Pfam: PF06574,PF01687; InterPro: IPR002606; Belongs to the ribF family. | 0.915 |
EEW53280.1 | ribH | HMPREF0494_1563 | HMPREF0494_0463 | Cof-like hydrolase; COG: COG0561; Pfam: PF08282; InterPro: IPR000150. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.912 |
EEW54456.1 | ribE | HMPREF0494_0344 | HMPREF0494_0461 | Flavin reductase; COG: COG0431; Pfam: PF03358; InterPro: IPR005025. | Riboflavin synthase, alpha subunit; COG: COG0307; Pfam: PF00677; InterPro: IPR001783. | 0.470 |
EEW54456.1 | ribF | HMPREF0494_0344 | HMPREF0494_1427 | Flavin reductase; COG: COG0431; Pfam: PF03358; InterPro: IPR005025. | Riboflavin biosynthesis protein RibF; COG: COG0196; Pfam: PF06574,PF01687; InterPro: IPR002606; Belongs to the ribF family. | 0.505 |
nox | ribE | HMPREF0494_1229 | HMPREF0494_0461 | NADH oxidase; COG: COG0446; Pfam: PF07992,PF00070,PF02852; InterPro: IPR013027. | Riboflavin synthase, alpha subunit; COG: COG0307; Pfam: PF00677; InterPro: IPR001783. | 0.687 |
nox | rpmE | HMPREF0494_1229 | HMPREF0494_0220 | NADH oxidase; COG: COG0446; Pfam: PF07992,PF00070,PF02852; InterPro: IPR013027. | Ribosomal protein L31; COG: COG0254; Pfam: PF01197; InterPro: IPR002150. | 0.687 |
pgmB | ribD | HMPREF0494_0360 | HMPREF0494_0460 | Beta-phosphoglucomutase; COG: COG0637; Pfam: PF00702; InterPro: IPR005834. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.911 |
pgmB | ribE | HMPREF0494_0360 | HMPREF0494_0461 | Beta-phosphoglucomutase; COG: COG0637; Pfam: PF00702; InterPro: IPR005834. | Riboflavin synthase, alpha subunit; COG: COG0307; Pfam: PF00677; InterPro: IPR001783. | 0.484 |
pgmB | ribF | HMPREF0494_0360 | HMPREF0494_1427 | Beta-phosphoglucomutase; COG: COG0637; Pfam: PF00702; InterPro: IPR005834. | Riboflavin biosynthesis protein RibF; COG: COG0196; Pfam: PF06574,PF01687; InterPro: IPR002606; Belongs to the ribF family. | 0.504 |
pgmB | ribH | HMPREF0494_0360 | HMPREF0494_0463 | Beta-phosphoglucomutase; COG: COG0637; Pfam: PF00702; InterPro: IPR005834. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.476 |
ribA | EEW53280.1 | HMPREF0494_0462 | HMPREF0494_1563 | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | Cof-like hydrolase; COG: COG0561; Pfam: PF08282; InterPro: IPR000150. | 0.490 |
ribA | ribB | HMPREF0494_0462 | HMPREF0494_0494 | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. Belongs to the DHBP synthase family. | 0.964 |
ribA | ribD | HMPREF0494_0462 | HMPREF0494_0460 | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.999 |
ribA | ribE | HMPREF0494_0462 | HMPREF0494_0461 | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | Riboflavin synthase, alpha subunit; COG: COG0307; Pfam: PF00677; InterPro: IPR001783. | 0.999 |
ribA | ribF | HMPREF0494_0462 | HMPREF0494_1427 | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | Riboflavin biosynthesis protein RibF; COG: COG0196; Pfam: PF06574,PF01687; InterPro: IPR002606; Belongs to the ribF family. | 0.838 |
ribA | ribH | HMPREF0494_0462 | HMPREF0494_0463 | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.999 |