node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEW52768.1 | clpC | HMPREF0494_2053 | HMPREF0494_0816 | Hypothetical protein. | ATPase family associated with various cellular activities (AAA); COG: COG0542; Pfam: PF02861,PF00004,PF02151,PF07724; InterPro: IPR003593; Belongs to the ClpA/ClpB family. | 0.888 |
EEW52768.1 | clpP | HMPREF0494_2053 | HMPREF0494_0886 | Hypothetical protein. | Endopeptidase Clp; COG: COG0740; Pfam: PF00574; InterPro: IPR001907; Belongs to the peptidase S14 family. | 0.539 |
EEW52768.1 | clpP-2 | HMPREF0494_2053 | HMPREF0494_1043 | Hypothetical protein. | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.539 |
EEW52768.1 | dnaJ | HMPREF0494_2053 | HMPREF0494_1432 | Hypothetical protein. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.972 |
EEW52768.1 | grpE | HMPREF0494_2053 | HMPREF0494_1430 | Hypothetical protein. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.956 |
EEW52768.1 | hsp | HMPREF0494_2053 | HMPREF0494_1105 | Hypothetical protein. | Hsp20/alpha crystallin family protein; COG: COG0071; Pfam: PF00011; InterPro: IPR002068; Belongs to the small heat shock protein (HSP20) family. | 0.615 |
EEW52768.1 | rpoB | HMPREF0494_2053 | HMPREF0494_0818 | Hypothetical protein. | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.405 |
clpC | EEW52768.1 | HMPREF0494_0816 | HMPREF0494_2053 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Pfam: PF02861,PF00004,PF02151,PF07724; InterPro: IPR003593; Belongs to the ClpA/ClpB family. | Hypothetical protein. | 0.888 |
clpC | clpP | HMPREF0494_0816 | HMPREF0494_0886 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Pfam: PF02861,PF00004,PF02151,PF07724; InterPro: IPR003593; Belongs to the ClpA/ClpB family. | Endopeptidase Clp; COG: COG0740; Pfam: PF00574; InterPro: IPR001907; Belongs to the peptidase S14 family. | 0.801 |
clpC | clpP-2 | HMPREF0494_0816 | HMPREF0494_1043 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Pfam: PF02861,PF00004,PF02151,PF07724; InterPro: IPR003593; Belongs to the ClpA/ClpB family. | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.916 |
clpC | ctsR | HMPREF0494_0816 | HMPREF0494_0815 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Pfam: PF02861,PF00004,PF02151,PF07724; InterPro: IPR003593; Belongs to the ClpA/ClpB family. | Transcriptional repressor of CtsR; COG: COG4463; Pfam: PF05848; InterPro: IPR008463; Belongs to the CtsR family. | 0.960 |
clpC | dnaJ | HMPREF0494_0816 | HMPREF0494_1432 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Pfam: PF02861,PF00004,PF02151,PF07724; InterPro: IPR003593; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.851 |
clpC | dnaK | HMPREF0494_0816 | HMPREF0494_1431 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Pfam: PF02861,PF00004,PF02151,PF07724; InterPro: IPR003593; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.937 |
clpC | grpE | HMPREF0494_0816 | HMPREF0494_1430 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Pfam: PF02861,PF00004,PF02151,PF07724; InterPro: IPR003593; Belongs to the ClpA/ClpB family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.839 |
clpC | hsp | HMPREF0494_0816 | HMPREF0494_1105 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Pfam: PF02861,PF00004,PF02151,PF07724; InterPro: IPR003593; Belongs to the ClpA/ClpB family. | Hsp20/alpha crystallin family protein; COG: COG0071; Pfam: PF00011; InterPro: IPR002068; Belongs to the small heat shock protein (HSP20) family. | 0.856 |
clpC | mecA | HMPREF0494_0816 | HMPREF0494_1305 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Pfam: PF02861,PF00004,PF02151,PF07724; InterPro: IPR003593; Belongs to the ClpA/ClpB family. | Negative regulator of genetic competence (MecA); Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis; Belongs to the MecA family. | 0.760 |
clpC | rpoB | HMPREF0494_0816 | HMPREF0494_0818 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Pfam: PF02861,PF00004,PF02151,PF07724; InterPro: IPR003593; Belongs to the ClpA/ClpB family. | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.769 |
clpP | EEW52768.1 | HMPREF0494_0886 | HMPREF0494_2053 | Endopeptidase Clp; COG: COG0740; Pfam: PF00574; InterPro: IPR001907; Belongs to the peptidase S14 family. | Hypothetical protein. | 0.539 |
clpP | clpC | HMPREF0494_0886 | HMPREF0494_0816 | Endopeptidase Clp; COG: COG0740; Pfam: PF00574; InterPro: IPR001907; Belongs to the peptidase S14 family. | ATPase family associated with various cellular activities (AAA); COG: COG0542; Pfam: PF02861,PF00004,PF02151,PF07724; InterPro: IPR003593; Belongs to the ClpA/ClpB family. | 0.801 |
clpP | dnaJ | HMPREF0494_0886 | HMPREF0494_1432 | Endopeptidase Clp; COG: COG0740; Pfam: PF00574; InterPro: IPR001907; Belongs to the peptidase S14 family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.585 |