| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEJ72538.1 | EEJ73045.1 | HMPREF0548_0589 | HMPREF0548_0026 | Putative permease; COG: COG2233. | Putative carbamoyl-phosphate synthase, large subunit; COG: COG0458; Belongs to the CarB family. | 0.711 |
| EEJ72538.1 | EEJ73046.1 | HMPREF0548_0589 | HMPREF0548_0027 | Putative permease; COG: COG2233. | Putative carbamoyl-phosphate synthase, small subunit; COG: COG0505. | 0.789 |
| EEJ72538.1 | carA | HMPREF0548_0589 | HMPREF0548_0209 | Putative permease; COG: COG2233. | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Belongs to the CarA family. | 0.789 |
| EEJ72538.1 | carB | HMPREF0548_0589 | HMPREF0548_0208 | Putative permease; COG: COG2233. | Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Belongs to the CarB family. | 0.711 |
| EEJ72538.1 | pyrB | HMPREF0548_0589 | HMPREF0548_0211 | Putative permease; COG: COG2233. | Aspartate carbamoyltransferase; COG: COG0540; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
| EEJ72538.1 | pyrC | HMPREF0548_0589 | HMPREF0548_0210 | Putative permease; COG: COG2233. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.996 |
| EEJ72538.1 | pyrD | HMPREF0548_0589 | HMPREF0548_0213 | Putative permease; COG: COG2233. | Dihydroorotate dehydrogenase 1B; Catalyzes the conversion of dihydroorotate to orotate. | 0.868 |
| EEJ72538.1 | pyrF | HMPREF0548_0589 | HMPREF0548_0214 | Putative permease; COG: COG2233. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.966 |
| EEJ72538.1 | pyrR1 | HMPREF0548_0589 | HMPREF0548_0590 | Putative permease; COG: COG2233. | Phosphoribosyl transferase domain protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.990 |
| EEJ72538.1 | pyrR2 | HMPREF0548_0589 | HMPREF0548_0212 | Putative permease; COG: COG2233. | Phosphoribosyl transferase domain protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.959 |
| EEJ73045.1 | EEJ72538.1 | HMPREF0548_0026 | HMPREF0548_0589 | Putative carbamoyl-phosphate synthase, large subunit; COG: COG0458; Belongs to the CarB family. | Putative permease; COG: COG2233. | 0.711 |
| EEJ73045.1 | EEJ73046.1 | HMPREF0548_0026 | HMPREF0548_0027 | Putative carbamoyl-phosphate synthase, large subunit; COG: COG0458; Belongs to the CarB family. | Putative carbamoyl-phosphate synthase, small subunit; COG: COG0505. | 0.999 |
| EEJ73045.1 | carA | HMPREF0548_0026 | HMPREF0548_0209 | Putative carbamoyl-phosphate synthase, large subunit; COG: COG0458; Belongs to the CarB family. | Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Belongs to the CarA family. | 0.999 |
| EEJ73045.1 | pyrB | HMPREF0548_0026 | HMPREF0548_0211 | Putative carbamoyl-phosphate synthase, large subunit; COG: COG0458; Belongs to the CarB family. | Aspartate carbamoyltransferase; COG: COG0540; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
| EEJ73045.1 | pyrC | HMPREF0548_0026 | HMPREF0548_0210 | Putative carbamoyl-phosphate synthase, large subunit; COG: COG0458; Belongs to the CarB family. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.997 |
| EEJ73045.1 | pyrD | HMPREF0548_0026 | HMPREF0548_0213 | Putative carbamoyl-phosphate synthase, large subunit; COG: COG0458; Belongs to the CarB family. | Dihydroorotate dehydrogenase 1B; Catalyzes the conversion of dihydroorotate to orotate. | 0.902 |
| EEJ73045.1 | pyrF | HMPREF0548_0026 | HMPREF0548_0214 | Putative carbamoyl-phosphate synthase, large subunit; COG: COG0458; Belongs to the CarB family. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.960 |
| EEJ73045.1 | pyrR1 | HMPREF0548_0026 | HMPREF0548_0590 | Putative carbamoyl-phosphate synthase, large subunit; COG: COG0458; Belongs to the CarB family. | Phosphoribosyl transferase domain protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.686 |
| EEJ73045.1 | pyrR2 | HMPREF0548_0026 | HMPREF0548_0212 | Putative carbamoyl-phosphate synthase, large subunit; COG: COG0458; Belongs to the CarB family. | Phosphoribosyl transferase domain protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.686 |
| EEJ73046.1 | EEJ72538.1 | HMPREF0548_0027 | HMPREF0548_0589 | Putative carbamoyl-phosphate synthase, small subunit; COG: COG0505. | Putative permease; COG: COG2233. | 0.789 |