| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEJ71178.1 | EEJ72294.1 | HMPREF0548_1910 | HMPREF0548_0816 | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Creatinase; COG: COG0006. | 0.682 |
| EEJ71178.1 | glyA | HMPREF0548_1910 | HMPREF0548_2006 | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.443 |
| EEJ71178.1 | guaC | HMPREF0548_1910 | HMPREF0548_1455 | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.949 |
| EEJ71178.1 | pepQ | HMPREF0548_1910 | HMPREF0548_2199 | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Xaa-Pro dipeptidase; COG: COG0006; Belongs to the peptidase M24B family. | 0.682 |
| EEJ71178.1 | pepT-2 | HMPREF0548_1910 | HMPREF0548_0330 | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Peptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family. | 0.587 |
| EEJ71899.1 | EEJ72294.1 | HMPREF0548_1141 | HMPREF0548_0816 | Pyridine nucleotide-disulfide oxidoreductase; COG: COG0446. | Creatinase; COG: COG0006. | 0.537 |
| EEJ71899.1 | glyA | HMPREF0548_1141 | HMPREF0548_2006 | Pyridine nucleotide-disulfide oxidoreductase; COG: COG0446. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.708 |
| EEJ71899.1 | pepN | HMPREF0548_1141 | HMPREF0548_1494 | Pyridine nucleotide-disulfide oxidoreductase; COG: COG0446. | Membrane alanyl aminopeptidase; COG: COG0308. | 0.537 |
| EEJ71899.1 | pepQ | HMPREF0548_1141 | HMPREF0548_2199 | Pyridine nucleotide-disulfide oxidoreductase; COG: COG0446. | Xaa-Pro dipeptidase; COG: COG0006; Belongs to the peptidase M24B family. | 0.528 |
| EEJ71899.1 | pepT-2 | HMPREF0548_1141 | HMPREF0548_0330 | Pyridine nucleotide-disulfide oxidoreductase; COG: COG0446. | Peptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family. | 0.552 |
| EEJ72294.1 | EEJ71178.1 | HMPREF0548_0816 | HMPREF0548_1910 | Creatinase; COG: COG0006. | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.682 |
| EEJ72294.1 | EEJ71899.1 | HMPREF0548_0816 | HMPREF0548_1141 | Creatinase; COG: COG0006. | Pyridine nucleotide-disulfide oxidoreductase; COG: COG0446. | 0.537 |
| EEJ72294.1 | guaC | HMPREF0548_0816 | HMPREF0548_1455 | Creatinase; COG: COG0006. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.682 |
| EEJ72294.1 | pepN | HMPREF0548_0816 | HMPREF0548_1494 | Creatinase; COG: COG0006. | Membrane alanyl aminopeptidase; COG: COG0308. | 0.730 |
| EEJ72294.1 | pepT-2 | HMPREF0548_0816 | HMPREF0548_0330 | Creatinase; COG: COG0006. | Peptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family. | 0.707 |
| EEJ72870.1 | ltrA | HMPREF0548_0331 | HMPREF0548_0329 | Lactate/malate dehydrogenase, NAD binding domain protein; COG: COG0039; Belongs to the LDH/MDH superfamily. | Low temperature requirement protein LtrA. | 0.478 |
| EEJ72870.1 | pepT-2 | HMPREF0548_0331 | HMPREF0548_0330 | Lactate/malate dehydrogenase, NAD binding domain protein; COG: COG0039; Belongs to the LDH/MDH superfamily. | Peptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family. | 0.590 |
| ddl | pepT-2 | HMPREF0548_1771 | HMPREF0548_0330 | D-ala D-ala ligase N-terminal domain protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Peptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family. | 0.527 |
| glyA | EEJ71178.1 | HMPREF0548_2006 | HMPREF0548_1910 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.443 |
| glyA | EEJ71899.1 | HMPREF0548_2006 | HMPREF0548_1141 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Pyridine nucleotide-disulfide oxidoreductase; COG: COG0446. | 0.708 |