| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEJ71738.1 | EEJ73018.1 | HMPREF0548_1351 | HMPREF0548_0135 | DHHA1 domain protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. | GIY-YIG catalytic domain protein; COG: COG4123. | 0.435 |
| EEJ71738.1 | ecfT | HMPREF0548_1351 | HMPREF0548_2073 | DHHA1 domain protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. | Cobalt transport protein; Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. | 0.450 |
| EEJ71738.1 | polC | HMPREF0548_1351 | HMPREF0548_0126 | DHHA1 domain protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. | DNA polymerase III, alpha subunit, Gram-positive type; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.622 |
| EEJ71738.1 | tmcAL | HMPREF0548_1351 | HMPREF0548_0342 | DHHA1 domain protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. | Hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac- AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. | 0.708 |
| EEJ72743.1 | EEJ72744.1 | HMPREF0548_0343 | HMPREF0548_0344 | Iojap-like protein. | Hydrolase, HD family; COG: COG1713. | 0.933 |
| EEJ72743.1 | EEJ72880.1 | HMPREF0548_0343 | HMPREF0548_0341 | Iojap-like protein. | Putative ACR, COG1399; COG: COG1399. | 0.673 |
| EEJ72743.1 | nadD | HMPREF0548_0343 | HMPREF0548_0345 | Iojap-like protein. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.940 |
| EEJ72743.1 | tmcAL | HMPREF0548_0343 | HMPREF0548_0342 | Iojap-like protein. | Hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac- AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. | 0.664 |
| EEJ72743.1 | yqeG | HMPREF0548_0343 | HMPREF0548_0347 | Iojap-like protein. | HAD phosphatase, family IIIA; COG: COG2179. | 0.838 |
| EEJ72743.1 | yqeH | HMPREF0548_0343 | HMPREF0548_0346 | Iojap-like protein. | Ribosome biogenesis GTPase YqeH; COG: COG1161. | 0.972 |
| EEJ72744.1 | EEJ72743.1 | HMPREF0548_0344 | HMPREF0548_0343 | Hydrolase, HD family; COG: COG1713. | Iojap-like protein. | 0.933 |
| EEJ72744.1 | EEJ72880.1 | HMPREF0548_0344 | HMPREF0548_0341 | Hydrolase, HD family; COG: COG1713. | Putative ACR, COG1399; COG: COG1399. | 0.679 |
| EEJ72744.1 | nadD | HMPREF0548_0344 | HMPREF0548_0345 | Hydrolase, HD family; COG: COG1713. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.997 |
| EEJ72744.1 | polC | HMPREF0548_0344 | HMPREF0548_0126 | Hydrolase, HD family; COG: COG1713. | DNA polymerase III, alpha subunit, Gram-positive type; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.738 |
| EEJ72744.1 | tmcAL | HMPREF0548_0344 | HMPREF0548_0342 | Hydrolase, HD family; COG: COG1713. | Hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac- AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. | 0.810 |
| EEJ72744.1 | yqeG | HMPREF0548_0344 | HMPREF0548_0347 | Hydrolase, HD family; COG: COG1713. | HAD phosphatase, family IIIA; COG: COG2179. | 0.895 |
| EEJ72744.1 | yqeH | HMPREF0548_0344 | HMPREF0548_0346 | Hydrolase, HD family; COG: COG1713. | Ribosome biogenesis GTPase YqeH; COG: COG1161. | 0.915 |
| EEJ72880.1 | EEJ72743.1 | HMPREF0548_0341 | HMPREF0548_0343 | Putative ACR, COG1399; COG: COG1399. | Iojap-like protein. | 0.673 |
| EEJ72880.1 | EEJ72744.1 | HMPREF0548_0341 | HMPREF0548_0344 | Putative ACR, COG1399; COG: COG1399. | Hydrolase, HD family; COG: COG1713. | 0.679 |
| EEJ72880.1 | nadD | HMPREF0548_0341 | HMPREF0548_0345 | Putative ACR, COG1399; COG: COG1399. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.666 |