| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEJ72500.1 | EEJ72502.1 | HMPREF0548_0624 | HMPREF0548_0626 | Formate C-acetyltransferase; COG: COG1882. | Putative sugar-binding domain protein; COG: COG2390. | 0.668 |
| EEJ72500.1 | lacR | HMPREF0548_0624 | HMPREF0548_0625 | Formate C-acetyltransferase; COG: COG1882. | Transcriptional regulator, DeoR family; COG: COG1349. | 0.601 |
| EEJ72500.1 | pflC | HMPREF0548_0624 | HMPREF0548_0623 | Formate C-acetyltransferase; COG: COG1882. | Glycyl-radical enzyme activating protein family protein; COG: COG1180. | 0.988 |
| EEJ72500.1 | tal1 | HMPREF0548_0624 | HMPREF0548_0627 | Formate C-acetyltransferase; COG: COG1882. | Fructose-6-phosphate aldolase; COG: COG0176. | 0.670 |
| EEJ72502.1 | EEJ72500.1 | HMPREF0548_0626 | HMPREF0548_0624 | Putative sugar-binding domain protein; COG: COG2390. | Formate C-acetyltransferase; COG: COG1882. | 0.668 |
| EEJ72502.1 | lacR | HMPREF0548_0626 | HMPREF0548_0625 | Putative sugar-binding domain protein; COG: COG2390. | Transcriptional regulator, DeoR family; COG: COG1349. | 0.824 |
| EEJ72502.1 | pflC | HMPREF0548_0626 | HMPREF0548_0623 | Putative sugar-binding domain protein; COG: COG2390. | Glycyl-radical enzyme activating protein family protein; COG: COG1180. | 0.542 |
| EEJ72502.1 | tal1 | HMPREF0548_0626 | HMPREF0548_0627 | Putative sugar-binding domain protein; COG: COG2390. | Fructose-6-phosphate aldolase; COG: COG0176. | 0.732 |
| fruA | fruR | HMPREF0548_1565 | HMPREF0548_1563 | Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; COG: COG1299. | Transcriptional regulator, DeoR family; COG: COG1349. | 0.953 |
| fruA | frwB | HMPREF0548_1565 | HMPREF0548_0629 | Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; COG: COG1299. | Fructose-like phosphotransferase enzyme IIB component 2; COG: COG1445. | 0.956 |
| fruA | lacR | HMPREF0548_1565 | HMPREF0548_0625 | Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; COG: COG1299. | Transcriptional regulator, DeoR family; COG: COG1349. | 0.791 |
| fruA | pfkB | HMPREF0548_1565 | HMPREF0548_1564 | Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; COG: COG1299. | 1-phosphofructokinase; COG: COG1105; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. | 0.999 |
| fruA | rbsK | HMPREF0548_1565 | HMPREF0548_0613 | Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; COG: COG1299. | Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. | 0.982 |
| fruA | tal1 | HMPREF0548_1565 | HMPREF0548_0627 | Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; COG: COG1299. | Fructose-6-phosphate aldolase; COG: COG0176. | 0.509 |
| fruR | fruA | HMPREF0548_1563 | HMPREF0548_1565 | Transcriptional regulator, DeoR family; COG: COG1349. | Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; COG: COG1299. | 0.953 |
| fruR | lacR | HMPREF0548_1563 | HMPREF0548_0625 | Transcriptional regulator, DeoR family; COG: COG1349. | Transcriptional regulator, DeoR family; COG: COG1349. | 0.775 |
| fruR | pfkB | HMPREF0548_1563 | HMPREF0548_1564 | Transcriptional regulator, DeoR family; COG: COG1349. | 1-phosphofructokinase; COG: COG1105; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. | 0.974 |
| fruR | rbsK | HMPREF0548_1563 | HMPREF0548_0613 | Transcriptional regulator, DeoR family; COG: COG1349. | Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. | 0.497 |
| fruR | rpiA | HMPREF0548_1563 | HMPREF0548_0614 | Transcriptional regulator, DeoR family; COG: COG1349. | Ribose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. | 0.440 |
| frwB | fruA | HMPREF0548_0629 | HMPREF0548_1565 | Fructose-like phosphotransferase enzyme IIB component 2; COG: COG1445. | Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; COG: COG1299. | 0.956 |