node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEJ72233.1 | sufS | HMPREF0548_0920 | HMPREF0548_0633 | Transcriptional regulator, AraC family. | Cysteine desulfurase, SufS subfamily; COG: COG0520; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. | 0.942 |
EEJ72510.1 | EEJ72512.1 | HMPREF0548_0634 | HMPREF0548_0636 | SUF system FeS assembly protein, NifU family; COG: COG0822. | Hypothetical protein; COG: COG2151. | 0.910 |
EEJ72510.1 | mntH | HMPREF0548_0634 | HMPREF0548_0637 | SUF system FeS assembly protein, NifU family; COG: COG0822. | Metal ion transporter, metal ion (Mn2+/Fe2+) transporter (Nramp) family; H(+)-stimulated, divalent metal cation uptake system. Belongs to the NRAMP family. | 0.778 |
EEJ72510.1 | sufB | HMPREF0548_0634 | HMPREF0548_0635 | SUF system FeS assembly protein, NifU family; COG: COG0822. | FeS assembly protein SufB; COG: COG0719. | 0.977 |
EEJ72510.1 | sufC | HMPREF0548_0634 | HMPREF0548_0631 | SUF system FeS assembly protein, NifU family; COG: COG0822. | FeS assembly ATPase SufC; COG: COG0396. | 0.977 |
EEJ72510.1 | sufD | HMPREF0548_0634 | HMPREF0548_0632 | SUF system FeS assembly protein, NifU family; COG: COG0822. | FeS assembly protein SufD; COG: COG0719. | 0.987 |
EEJ72510.1 | sufS | HMPREF0548_0634 | HMPREF0548_0633 | SUF system FeS assembly protein, NifU family; COG: COG0822. | Cysteine desulfurase, SufS subfamily; COG: COG0520; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. | 0.999 |
EEJ72510.1 | trxB | HMPREF0548_0634 | HMPREF0548_0713 | SUF system FeS assembly protein, NifU family; COG: COG0822. | Thioredoxin-disulfide reductase; COG: COG0492. | 0.437 |
EEJ72510.1 | trxB-2 | HMPREF0548_0634 | HMPREF0548_2158 | SUF system FeS assembly protein, NifU family; COG: COG0822. | Thioredoxin-disulfide reductase; COG: COG0492. | 0.437 |
EEJ72512.1 | EEJ72510.1 | HMPREF0548_0636 | HMPREF0548_0634 | Hypothetical protein; COG: COG2151. | SUF system FeS assembly protein, NifU family; COG: COG0822. | 0.910 |
EEJ72512.1 | glyA | HMPREF0548_0636 | HMPREF0548_2006 | Hypothetical protein; COG: COG2151. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.436 |
EEJ72512.1 | mntH | HMPREF0548_0636 | HMPREF0548_0637 | Hypothetical protein; COG: COG2151. | Metal ion transporter, metal ion (Mn2+/Fe2+) transporter (Nramp) family; H(+)-stimulated, divalent metal cation uptake system. Belongs to the NRAMP family. | 0.763 |
EEJ72512.1 | sufB | HMPREF0548_0636 | HMPREF0548_0635 | Hypothetical protein; COG: COG2151. | FeS assembly protein SufB; COG: COG0719. | 0.804 |
EEJ72512.1 | sufC | HMPREF0548_0636 | HMPREF0548_0631 | Hypothetical protein; COG: COG2151. | FeS assembly ATPase SufC; COG: COG0396. | 0.873 |
EEJ72512.1 | sufD | HMPREF0548_0636 | HMPREF0548_0632 | Hypothetical protein; COG: COG2151. | FeS assembly protein SufD; COG: COG0719. | 0.840 |
EEJ72512.1 | sufS | HMPREF0548_0636 | HMPREF0548_0633 | Hypothetical protein; COG: COG2151. | Cysteine desulfurase, SufS subfamily; COG: COG0520; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. | 0.847 |
glyA | EEJ72512.1 | HMPREF0548_2006 | HMPREF0548_0636 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Hypothetical protein; COG: COG2151. | 0.436 |
glyA | sufS | HMPREF0548_2006 | HMPREF0548_0633 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Cysteine desulfurase, SufS subfamily; COG: COG0520; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. | 0.687 |
glyA | trxB | HMPREF0548_2006 | HMPREF0548_0713 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Thioredoxin-disulfide reductase; COG: COG0492. | 0.501 |
glyA | trxB-2 | HMPREF0548_2006 | HMPREF0548_2158 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Thioredoxin-disulfide reductase; COG: COG0492. | 0.501 |