| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEJ72870.1 | ilvE | HMPREF0548_0331 | HMPREF0548_0812 | Lactate/malate dehydrogenase, NAD binding domain protein; COG: COG0039; Belongs to the LDH/MDH superfamily. | Branched-chain-amino-acid transaminase; COG: COG0115. | 0.944 |
| EEJ72870.1 | ldh | HMPREF0548_0331 | HMPREF0548_2022 | Lactate/malate dehydrogenase, NAD binding domain protein; COG: COG0039; Belongs to the LDH/MDH superfamily. | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. | 0.910 |
| EEJ72870.1 | ldh2 | HMPREF0548_0331 | HMPREF0548_0952 | Lactate/malate dehydrogenase, NAD binding domain protein; COG: COG0039; Belongs to the LDH/MDH superfamily. | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. | 0.914 |
| EEJ72870.1 | oxc | HMPREF0548_0331 | HMPREF0548_2147 | Lactate/malate dehydrogenase, NAD binding domain protein; COG: COG0039; Belongs to the LDH/MDH superfamily. | oxalyl-CoA decarboxylase; COG: COG0028; Belongs to the TPP enzyme family. | 0.482 |
| EEJ72870.1 | spxB | HMPREF0548_0331 | HMPREF0548_1367 | Lactate/malate dehydrogenase, NAD binding domain protein; COG: COG0039; Belongs to the LDH/MDH superfamily. | Pyruvate oxidase; COG: COG0028; Belongs to the TPP enzyme family. | 0.948 |
| EEJ73104.1 | ilvE | HMPREF0548_0085 | HMPREF0548_0812 | Homoserine dehydrogenase; COG: COG0460. | Branched-chain-amino-acid transaminase; COG: COG0115. | 0.965 |
| EEJ73104.1 | spxB | HMPREF0548_0085 | HMPREF0548_1367 | Homoserine dehydrogenase; COG: COG0460. | Pyruvate oxidase; COG: COG0028; Belongs to the TPP enzyme family. | 0.539 |
| EEJ73104.1 | thrB | HMPREF0548_0085 | HMPREF0548_0084 | Homoserine dehydrogenase; COG: COG0460. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.999 |
| alr | ddl | HMPREF0548_2018 | HMPREF0548_1771 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | D-ala D-ala ligase N-terminal domain protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | 0.984 |
| alr | dltA | HMPREF0548_2018 | HMPREF0548_1420 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | D-alanine--poly(phosphoribitol) ligase, subunit 1; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to [...] | 0.951 |
| alr | ilvE | HMPREF0548_2018 | HMPREF0548_0812 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Branched-chain-amino-acid transaminase; COG: COG0115. | 0.705 |
| ddl | alr | HMPREF0548_1771 | HMPREF0548_2018 | D-ala D-ala ligase N-terminal domain protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.984 |
| ddl | dltA | HMPREF0548_1771 | HMPREF0548_1420 | D-ala D-ala ligase N-terminal domain protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | D-alanine--poly(phosphoribitol) ligase, subunit 1; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to [...] | 0.959 |
| ddl | ilvE | HMPREF0548_1771 | HMPREF0548_0812 | D-ala D-ala ligase N-terminal domain protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Branched-chain-amino-acid transaminase; COG: COG0115. | 0.705 |
| dltA | alr | HMPREF0548_1420 | HMPREF0548_2018 | D-alanine--poly(phosphoribitol) ligase, subunit 1; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to [...] | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.951 |
| dltA | ddl | HMPREF0548_1420 | HMPREF0548_1771 | D-alanine--poly(phosphoribitol) ligase, subunit 1; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to [...] | D-ala D-ala ligase N-terminal domain protein; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | 0.959 |
| dltA | ilvE | HMPREF0548_1420 | HMPREF0548_0812 | D-alanine--poly(phosphoribitol) ligase, subunit 1; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to [...] | Branched-chain-amino-acid transaminase; COG: COG0115. | 0.714 |
| ilvE | EEJ72870.1 | HMPREF0548_0812 | HMPREF0548_0331 | Branched-chain-amino-acid transaminase; COG: COG0115. | Lactate/malate dehydrogenase, NAD binding domain protein; COG: COG0039; Belongs to the LDH/MDH superfamily. | 0.944 |
| ilvE | EEJ73104.1 | HMPREF0548_0812 | HMPREF0548_0085 | Branched-chain-amino-acid transaminase; COG: COG0115. | Homoserine dehydrogenase; COG: COG0460. | 0.965 |
| ilvE | alr | HMPREF0548_0812 | HMPREF0548_2018 | Branched-chain-amino-acid transaminase; COG: COG0115. | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.705 |