| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEJ71995.1 | EEJ72791.1 | HMPREF0548_1237 | HMPREF0548_0391 | Peptidyl-prolyl cis-trans isomerase, cyclophilin-type; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. | MIP family channel protein; COG: COG0580; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.760 |
| EEJ71995.1 | dnaJ | HMPREF0548_1237 | HMPREF0548_0113 | Peptidyl-prolyl cis-trans isomerase, cyclophilin-type; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.975 |
| EEJ71995.1 | ptc7 | HMPREF0548_1237 | HMPREF0548_0833 | Peptidyl-prolyl cis-trans isomerase, cyclophilin-type; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. | Protein phosphatase 2C; COG: COG0631. | 0.711 |
| EEJ72169.1 | dnaJ | HMPREF0548_0856 | HMPREF0548_0113 | Penicillin-binding protein, transpeptidase domain protein; COG: COG0768. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.773 |
| EEJ72169.1 | fmt | HMPREF0548_0856 | HMPREF0548_0831 | Penicillin-binding protein, transpeptidase domain protein; COG: COG0768. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.420 |
| EEJ72169.1 | priA | HMPREF0548_0856 | HMPREF0548_0830 | Penicillin-binding protein, transpeptidase domain protein; COG: COG0768. | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. | 0.439 |
| EEJ72169.1 | prkC | HMPREF0548_0856 | HMPREF0548_0834 | Penicillin-binding protein, transpeptidase domain protein; COG: COG0768. | Kinase domain protein; COG: COG0515. | 0.852 |
| EEJ72169.1 | ptc7 | HMPREF0548_0856 | HMPREF0548_0833 | Penicillin-binding protein, transpeptidase domain protein; COG: COG0768. | Protein phosphatase 2C; COG: COG0631. | 0.758 |
| EEJ72169.1 | rsgA | HMPREF0548_0856 | HMPREF0548_0835 | Penicillin-binding protein, transpeptidase domain protein; COG: COG0768. | Ribosome small subunit-dependent GTPase A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. | 0.441 |
| EEJ72791.1 | EEJ71995.1 | HMPREF0548_0391 | HMPREF0548_1237 | MIP family channel protein; COG: COG0580; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Peptidyl-prolyl cis-trans isomerase, cyclophilin-type; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. | 0.760 |
| EEJ72791.1 | dnaJ | HMPREF0548_0391 | HMPREF0548_0113 | MIP family channel protein; COG: COG0580; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.801 |
| EEJ72791.1 | ptc7 | HMPREF0548_0391 | HMPREF0548_0833 | MIP family channel protein; COG: COG0580; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Protein phosphatase 2C; COG: COG0631. | 0.745 |
| dnaJ | EEJ71995.1 | HMPREF0548_0113 | HMPREF0548_1237 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Peptidyl-prolyl cis-trans isomerase, cyclophilin-type; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. | 0.975 |
| dnaJ | EEJ72169.1 | HMPREF0548_0113 | HMPREF0548_0856 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Penicillin-binding protein, transpeptidase domain protein; COG: COG0768. | 0.773 |
| dnaJ | EEJ72791.1 | HMPREF0548_0113 | HMPREF0548_0391 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | MIP family channel protein; COG: COG0580; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.801 |
| dnaJ | ptc7 | HMPREF0548_0113 | HMPREF0548_0833 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Protein phosphatase 2C; COG: COG0631. | 0.745 |
| fmt | EEJ72169.1 | HMPREF0548_0831 | HMPREF0548_0856 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Penicillin-binding protein, transpeptidase domain protein; COG: COG0768. | 0.420 |
| fmt | gmk | HMPREF0548_0831 | HMPREF0548_0828 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.758 |
| fmt | priA | HMPREF0548_0831 | HMPREF0548_0830 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. | 0.963 |
| fmt | prkC | HMPREF0548_0831 | HMPREF0548_0834 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Kinase domain protein; COG: COG0515. | 0.865 |