node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEJ71016.1 | EEJ72406.1 | HMPREF0548_2127 | HMPREF0548_0739 | Hypothetical protein; COG: COG0470. | Exonuclease; COG: COG0847. | 0.962 |
EEJ71016.1 | dnaE | HMPREF0548_2127 | HMPREF0548_1002 | Hypothetical protein; COG: COG0470. | DNA polymerase III, alpha subunit; COG: COG0587. | 0.999 |
EEJ71016.1 | dnaN | HMPREF0548_2127 | HMPREF0548_1360 | Hypothetical protein; COG: COG0470. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.997 |
EEJ71016.1 | dnaX | HMPREF0548_2127 | HMPREF0548_2121 | Hypothetical protein; COG: COG0470. | DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.999 |
EEJ71016.1 | holA | HMPREF0548_2127 | HMPREF0548_0893 | Hypothetical protein; COG: COG0470. | DNA polymerase III, delta subunit; COG: COG1466. | 0.999 |
EEJ71016.1 | mutL | HMPREF0548_2127 | HMPREF0548_2174 | Hypothetical protein; COG: COG0470. | DNA mismatch repair domain protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.627 |
EEJ71016.1 | polA | HMPREF0548_2127 | HMPREF0548_0360 | Hypothetical protein; COG: COG0470. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.987 |
EEJ71016.1 | xth | HMPREF0548_2127 | HMPREF0548_1296 | Hypothetical protein; COG: COG0470. | Exodeoxyribonuclease III; COG: COG0708. | 0.752 |
EEJ72406.1 | EEJ71016.1 | HMPREF0548_0739 | HMPREF0548_2127 | Exonuclease; COG: COG0847. | Hypothetical protein; COG: COG0470. | 0.962 |
EEJ72406.1 | dnaE | HMPREF0548_0739 | HMPREF0548_1002 | Exonuclease; COG: COG0847. | DNA polymerase III, alpha subunit; COG: COG0587. | 0.988 |
EEJ72406.1 | dnaN | HMPREF0548_0739 | HMPREF0548_1360 | Exonuclease; COG: COG0847. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.989 |
EEJ72406.1 | dnaX | HMPREF0548_0739 | HMPREF0548_2121 | Exonuclease; COG: COG0847. | DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.989 |
EEJ72406.1 | holA | HMPREF0548_0739 | HMPREF0548_0893 | Exonuclease; COG: COG0847. | DNA polymerase III, delta subunit; COG: COG1466. | 0.986 |
EEJ72406.1 | polA | HMPREF0548_0739 | HMPREF0548_0360 | Exonuclease; COG: COG0847. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.844 |
dnaA | dnaN | HMPREF0548_1361 | HMPREF0548_1360 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.996 |
dnaA | dnaX | HMPREF0548_1361 | HMPREF0548_2121 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | DNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.538 |
dnaA | polA | HMPREF0548_1361 | HMPREF0548_0360 | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.667 |
dnaE | EEJ71016.1 | HMPREF0548_1002 | HMPREF0548_2127 | DNA polymerase III, alpha subunit; COG: COG0587. | Hypothetical protein; COG: COG0470. | 0.999 |
dnaE | EEJ72406.1 | HMPREF0548_1002 | HMPREF0548_0739 | DNA polymerase III, alpha subunit; COG: COG0587. | Exonuclease; COG: COG0847. | 0.988 |
dnaE | dnaN | HMPREF0548_1002 | HMPREF0548_1360 | DNA polymerase III, alpha subunit; COG: COG0587. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.999 |